Fracture Risk and Sodium-Glucose Transport Inhibitors

Nov 19, 2019

Editor: Steve Freed, R.PH., CDE

Author: Usif Darwish, PharmD Candidate, Florida A&M University, College of Pharmacy & Pharmaceutical Sciences

Did the FDA make a mistake by labeling SGLT2 inhibitors as a fracture risk?

In recent years, there have been controversial warnings for the use of SGLT-2 Inhibitors that suggest an increased risk of fracture when placed on one SGLT2 inhibitor, canagliflozin. In 2015, the US FDA added a warning on canagliflozin, indicating that patients on canagliflozin must use caution because of a fracture risk associated with the diabetes medication. This conclusion came from previous data....

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