Fenofibrate in combination with coenzyme Q10 (CoQ) appears to have a number of beneficial effects in type 2 diabetic subjects with mild left ventricular (LV) diastolic dysfunction, researchers report.
Investigator Dr. Gerald F. Watts of the University of Western Australia, stated that, "The results of this pilot study suggest that combined use of fenofibrate and CoQ could improve risk of cardiovascular disease in diabetic patients.
Dr. Watts and colleagues came to this conclusion after a double-blind study of 74 subjects who were randomized to receive either a combination of fenofibrate 160 mg and CoQ 200 mg daily, or either agent alone, or placebo.
None of the treatments had a significant effect on LV function. Combination therapy, however, prompted a significant reduction in 24-hour systolic blood pressure, with a prominent nocturnal effect. Both agents alone also led to a significant drop in 24 hour diastolic pressure.
In addition, fenofibrate reduced 24-hour heart rate by a significant 3.3 beats per minute. CoQ had no effect on heart rate.
The researchers point out that the approach did not improve diastolic function, but "we observed beneficial hemodynamic effects with no significant adverse cardiovascular sequelae."
However, concluded Dr. Watts, "this notion, based on favorable changes in blood pressure, heart rate and endothelial function, will need confirmation in a large clinical endpoint trial."
Diabetes Care 2008;31:1502-1509.
DID YOU KNOW:
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