Thursday , September 20 2018
Home / Conditions / MODY/LADA / Fenofibrate Combo Helps Curb Heart Problems in Diabetics

Fenofibrate Combo Helps Curb Heart Problems in Diabetics

Aug 26, 2008

Fenofibrate in combination with coenzyme Q10 (CoQ) appears to have a number of beneficial effects in type 2 diabetic subjects with mild left ventricular (LV) diastolic dysfunction, researchers report.

Investigator Dr. Gerald F. Watts of the University of Western Australia, stated that, "The results of this pilot study suggest that combined use of fenofibrate and CoQ could improve risk of cardiovascular disease in diabetic patients.

Dr. Watts and colleagues came to this conclusion after a double-blind study of 74 subjects who were randomized to receive either a combination of fenofibrate 160 mg and CoQ 200 mg daily, or either agent alone, or placebo.

None of the treatments had a significant effect on LV function. Combination therapy, however, prompted a significant reduction in 24-hour systolic blood pressure, with a prominent nocturnal effect. Both agents alone also led to a significant drop in 24 hour diastolic pressure.

In addition, fenofibrate reduced 24-hour heart rate by a significant 3.3 beats per minute. CoQ had no effect on heart rate.
The researchers point out that the approach did not improve diastolic function, but "we observed beneficial hemodynamic effects with no significant adverse cardiovascular sequelae."

However, concluded Dr. Watts, "this notion, based on favorable changes in blood pressure, heart rate and endothelial function, will need confirmation in a large clinical endpoint trial."

Diabetes Care 2008;31:1502-1509.



Popular BP Drugs May Cause Diabetes: Medications for blood pressure called beta blockers—like atenolol, inderal and metaprolol— could be an unacceptable risk for diabetes. Recent research in the UK indicates that these drugs could increase blood sugar in patients suffering from diabetes, and in some cases led to onset of the disease among patients of high blood pressure.  See This Weeks’ Item #1


Do you, or someone that you know, need guidance and support to deal with the challenges of weight, food and diabetes?
Fit4D offers diabetes coaching, delivered virtually through group class and 1:1 formats, supporting your individualized needs as a person living with diabetes, with an emphasis on nutrition, exercise, fitness, motivation, weight loss, blood sugar management and guidance.  In addition to providing you with a virtual support system,  Fit4D’s team of nurses, exercise physiologists, registered dietitians and personal trainers works with your existing doctors and medical providers to develop a customized, medically safe strategy of weight loss, diet and exercise that meets your unique personal needs and health care requirements.
Class and 1:1 diabetes coaching membership information is available at: or by calling 866-411-0254.  Mention Diabetes in Control and receive 10% off of upcoming classes or a 1:1 Personalized Coaching Membership!