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Eylea Bests Avastin, Lucentis in Diabetic Macular Edema

According to published data, treatment with aflibercept resulted in greater improvement in those with worse baseline levels of visual acuity…

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Aflibercept (Eylea), bevacizumab (Avastin) and ranibizumab (Lucentis) all improved vision in patients with diabetic macular edema, but treatment with aflibercept resulted in greater improvement. Paul A Sievivng, MD, PhD, director of the NIH’s National Eye Institute (NEI) which sponsored the study, said in a press release. "This comparative effectiveness study will help doctors and patients make informed decisions when choosing treatments for diabetic macular edema."

In the study, the researchers randomly assigned 660 adults (mean age, 61 years) at 89 clinical sites to receive intravitreous aflibercept 2.0 mg (n=224), bevacizumab 1.25 mg (n=218) or ranibizumab 0.3 mg (n=218), administered as often as every 4 weeks according to a protocol-specified algorithm.

All patients had diabetic macular edema involving the macular center. Ninety percent of patients had type 2 diabetes, with a mean duration of diabetes of 17 years. Mean baseline visual-acuity letter score was 64 (Snellen equivalent, 20/50), and mean central subfield thickness was 412 mcm.

Results showed that mean visual-acuity letter score (range, 0 to 100, with higher scores indicating better visual acuity, and a score of 85 being approximately 20/20) improved by 13.3 with aflibercept, 9.7 with bevacizumab and 11.2 with ranibizumab.

Although the researchers observed greater improvement with aflibercept compared with bevacizumab (P<.001) and ranibizumab (P=.03), the difference was not clinically meaningful, as it was primarily driven by eyes with worse baseline visual acuity (P<.001 for interaction).

Specifically, when the initial visual-acuity letter score was less than 69 (Snellen equivalent, 20/50 or worse), the mean improvement was 18.9 with aflibercept, 11.8 with bevacizumab and 14 with ranibizumab, respectively (P<.001 for aflibercept vs. bevacizumab, P=.003 for aflibercept vs. ranibizumab, and P=0.21 for ranibizumab vs. bevacizumab).

However, when visual-acuity letter score was 78 to 69 (equivalent to about 20/32 to 20/40), mean improvement was 8.0 with aflibercept, 7.5 with bevacizumab and 8.3 with ranibizumab (P>.50 for each pairwise comparison), suggesting the drugs were comparable in this patient population, according to the data.

The researchers also found that all three drugs reduced swelling of the macula, but aflibercept and ranibizumab reduced swelling more than bevacizumab. Further, fewer patients taking aflibercept underwent laser treatment for persistent edema that did not resolve with treatment alone vs. those on bevacizumab or ranibizumab (36% vs. 56% and 46%, respectively).

"Eylea, Avastin and Lucentis yield substantial gains in visual acuity for most people with diabetic macular edema; however, on average, Eylea appears to provide additional benefit for patients who start treatment with moderate or worse vision loss.

The researchers wrote, "Aflibercept should be considered as first-line therapy in [patients with a visual acuity of 20/50 or worse], with bevacizumab as the alternative given the lack of a significant difference in visual outcome between bevacizumab and ranibizumab and the large difference in cost between the two drugs."

Practice Pearls:

  • Results showed that mean visual-acuity letter improved by 13.3 with aflibercept, 9.7 with bevacizumab and 11.2 with ranibizumab.
  • When the initial visual-acuity letter score was less than 69, the mean improvement was 18.9 with aflibercept, 11.8 with bevacizumab and 14 with ranibizumab, respectively.
  • Aflibercept should be considered as first-line therapy in patients with a visual acuity of 20/50 or worse.

1 – The Diabetic Retinopathy Clinical Research Network. N Engl J Med. 2015;doi:10.1056/NEJMoa1414264.
2 – Martin DF, Maguire MG. N Engl J Med. 2015;doi:10.1056/NEJMe1