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Erectile Dysfunction Drugs Elevate Testosterone Levels

Oct 19, 2004

Treatment with sildenafil (Viagra) or tadalafil (Cialis) results in increased levels of testosterone in men with erectile dysfunction (ED). However, increases are more marked with tadalafil. Dr. Emmanuele A. Jannini from University of L’Aquila, Italy, stated that “We are now demonstrating the sexual and hormonal effect of two popular oral treatments for ED." "Both were efficacious and able to increase testosterone levels after 3 months of treatment."

Dr. Jannini and colleagues measured total and free testosterone levels before and after 3 months of type V phosphodiesterase inhibitor treatment in 74 consecutive men with erectile dysfunction.

Mean free testosterone levels increased from 59.9 pmol/L before treatment to 80.4 pmol/L after 3 months of treatment, the authors report. Total testosterone levels also rose (from 11.9 nmol/L to 16.3 nmol/L), while luteinizing hormone (LH) levels declined (from 4.7 IU/L to 2.7 IU/L).

The testosterone increases and LH decreases were more marked in the tadalafil group than in the sildenafil group, the report indicates, though the drugs were equally effective in restoring sexual potency.

The frequency of full sexual intercourse was also higher with tadalafil, despite the use of identical numbers of pills per month, the researchers note, "strongly suggesting that the greater normalization of hormonal values in tadalafil-treated patients was due to the higher number of sexual acts."

The investigators suggest that "the more evident increase in testosterone level is caused by the higher number of complete sexual acts performed by tadalafil-treated impotent men. In the context of a couple, this can be considered as an important benefit of tadalafil and a cost-effective advantage."

"For a man in a stable couple relationship, tadalafil is to be preferred," Dr. Jannini said. In this case, the drug can be taken twice a week to allow spontaneous sexual activity. "From a psycho-sexological point of view, this may help the patient to considered himself ‘cured’ and not simply ‘treated’ for the symptom." Clin Endocrinol 2004;61:382-386.


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