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Effects of Diabetes Medications on Heart Complications

Reduced risk of heart attacks, strokes, cardiovascular events suggested…

Type 2 diabetes has become more prevalent, along with the obesity epidemic. Type 2, which about 95 percent of diabetics have, is usually correlated to excess weight gain and a sedentary lifestyle. For many years, prescription medications, insulin, and other injected medicines together with regular physical activity and a healthy diet have helped diabetics control blood glucose levels and lose weight. Most patients don’t manage their diabetes as well as they should, though, which generally decreases their lifespan after years of polypharmacy. Jardiance is a newer class of diabetes medication and is a part of SGLT-2 inhibitors, which work by making the kidneys remove a significant amount of glucose from the blood to be excreted in urine. The manufacturing company of Jardiance, Eli Lilly and Co., funded a study that exhibited the benefits of Jardiance.

See more SGLT-2 Resources

In the Jardiance study, 7,000 patients were observed over three years, on average. Most of the patients were taking multiple medications for diabetes as well as other agents, to control blood glucose, blood pressure and cholesterol levels. The trial was designed as a placebo study. A portion of the studied population received Jardiance and the other portion received a placebo medication.

The actual results from this study have not been published. The two manufacturing companies, Eli Lilly and Co. of Indianapolis and German partner Boehringer Ingelheim GmbH, plan to release detailed results at a major diabetes conference in Europe on September 17 and simultaneously publish them in a medical journal. Without actual results, the true benefits of Jardiance is still unclear. With that in mind, the drug’s two manufacturers have announced that the study showed Jardiance reduced the risk of CV events when taken as part of the standard treatment for type 2 diabetes.

Practical Pearls:

  • Jardiance may serve as a protective heart medication for patients with diabetes and other cardiovascular damages.
  • Preliminary results for the Jardiance study suggest that Jardiance can delay the time until patients died of cardiovascular event.
  • Jardiance may have a huge effect on patients with diabetes who are taking multiple medications.

News release: Eli Lilly Aug 21, 2015