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Effect of Probiotic Supplements on Metabolic Profiles, hs-CRP, and Oxidative Stress in Type 2’s

In the current study, the results showed positive results in fasting plasma glucose and hs-CRP….

"Multispecies probiotic supplementation, compared with placebo, for 8 weeks in diabetic patients prevented a rise in FPG and resulted in a decrease in serum hs-CRP and an increase in plasma total GSH."

The goal for this study was to determine the effects of multispecies probiotic supplements on metabolic profiles, hs-CRP, and oxidative stress in diabetic patients. The design for this experiment was a randomized double-blind placebo-controlled clinical trial which was performed on 54 diabetic patients aged 35-70 years. All subjects in the study were randomly assigned to take either a multispecies probiotic supplement (n = 27) or placebo (n = 27) for 8 weeks. The probiotic consisted of 7 viable and freeze-dried strains including: Lactobacillus acidophilusL. caseiL. rhamnosusL. bulgaricusBifidobacterium breveB. longum, Streptococcus thermophilus and 100 mg fructo-oligosaccharide. Fasting blood samples were taken at baseline and after intervention to measure metabolic profiles, hs-CRP, and biomarkers of oxidative stress including plasma total antioxidant capacity and total glutathione. 

Results to the study showed that consumption of probiotic supplements prevented a rise in fasting plasma glucose (+28.8 ± 8.5 for placebo vs. +1.6 ± 6 mg/dl for probiotic group, p = 0.01). However, a significant increase in serum insulin and low-density lipoprotein cholesterol levels was found in both the probiotic group and the placebo group. A significant increase in HOMA-IR (homeostasis model of assessment-insulin resistance) was noted in both the probiotic group and the placebo group; however, the increase in the placebo group was significantly higher than that in the probiotic group. Mean changes in serum hs-CRP were significantly different between the two groups (-777.57 for the probiotic group vs. +878.72 ng/ml for the placebo group, p = 0.02). Overall, the study did suggest that probiotic supplementation was associated with a significant increase in plasma GSH levels compared to placebo. 

A final conclusion from the authors of this study suggested that a multispecies probiotic supplementation used for 8 weeks prevented an increase in fasting plasma glucose, decreased serum hs-CRP and increased total glutathione in diabetic patients.

Asem, Z, Z Zare, et al. "Effect of Multispecies Probiotic Supplements on Metabolic Profiles, hs-CRP, and Oxidative Stress in Patients with Type 2 Diabetes." Annals of Nutrition and Metabolism. Vol. 63, No. 1-2, Year 2013 . n. page. Web. 6 Jul. 2013.