When we sit down with our patients to talk about starting on GLP-1 analogs, we usually explain the main ways that they work. These are usually decreased glucagon release, less glucose dumping from the liver, increased and faster insulin secretion, slowing of gastric emptying and increased satiety. However there is a lot of research showing that native GLP-1 can also increase NHGU (net hepatic glucose uptake). What exactly is NHGU, how does it affect your patients’ glucose control, and could GLP-1 analogs help this process? Check out our feature article in this month’s GLP-1 Special Edition to find out more.