Monday , July 23 2018

Jan 21, 2016


The kidneys play a big part in controlling blood pressure. In fact, many of the major hypertensive medications have the root of their actions located in the kidneys. Diuretics work there, ACE inhibitors work there, as do the ARB’s, Spironolactone, and Triamterene.

Over the past 18-20 months we have been using the SGLT-2 inhibitors to lower glucose, and in many of these diabetes patients weight loss has been a bonus. These drugs also have their mechanism of action in the kidney, and seem to work by causing patients to eliminate the extra glucose that is reabsorbed because of the diabetes defect. With more than 7 million prescriptions filled for the class, we are seeing another benefit of this elimination of glucose: lower blood pressure levels. This month our issue is dedicated to understanding the possible role of SGLT-2 inhibitors in reducing blood pressure and improving cardiovascular health.

Your partner in diabetes care,
Dave Joffe