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Dietary Supplementation May Prevent Gestational Diabetes Mellitus

Apr 12, 2013

Myo-inositol reduces fetal macrosomia to 0% in patients at risk for GDM…. 

Data suggests myo-inositol supplementation correlates with a 9% reduction in gestational diabetes mellitus (GDM) for at risk mothers.


A randomized, controlled trial was performed using 110 non-obese gravidas, whose only risk factor for diabetes was a having a first-degree relative with diabetes. These women received 2 grams of myo-inositol twice daily along with 400 micrograms of folic acid twice daily from the end of the first trimester to the remainder of pregnancy. Controlled subjects received folic acid only.

Six percent of myo-inositol treated patients developed gestational diabetes, compared to 15% of controlled subjects. Also fetal macrosomia was reduced to 0% in at-risk for GDM patients compared to 7% in controls.

Myo-inositol can be found in many foods, particularly in fresh fruits and vegetables, beans, grain, and nuts. An average American diet containing 2500kcal/day was shown to contain approximately 900 mg of inositol. Mild GI side effects were only reported in studies using doses of 12 grams/day or greater. Placental transport late in pregnancy is presumed to be lower than 10%. However, caution is recommended with the use of inositol during pregnancy due to two studies suggesting it may stimulate uterine contraction, acting as a second messenger for oxytocin.

http://care.diabetesjournals.org/content/36/4/777.extract: Donald R. Coustan Can a Dietary Supplement Prevent Gestational Diabetes Mellitus? Diabetes Care April 2013 36:777-779; doi:10.2337/dc12-2505