Sulfonylurea

A 59 YOF is recently discharged from hospital after an allergic reaction to an anesthesia induction agent. She was placed on high-dose steroid for the reaction while she was in the hospital. Patient had completed her steroid tapering dose 2 months prior to her visit to endocrinology clinic today due to high blood glucose (a1c 8.9%). Past medical history included: hypertension, hyperlipidemia, atrial fibrillation, obesity and diabetes for 7 years. She was well controlled on metformin 1000mg BID before...

Low glucose events requiring emergency services differs according to diabetes type… Hypoglycemic episodes are a common event among patients with diabetes. Most hypoglycemic events are treated without ambulance services or admission to a hospital. However, severe hypoglycemic events are treated differently. Severe hypoglycemia is defined as “an episode requiring external …

The way that type 2 diabetics respond to initial treatment could predict the long term effectiveness of their treatment regimen… There are a variety of treatment options for type 2 diabetics, with no clear reason why some drugs work better than others in some individuals. That is why diabetes treatment …

GLP-1 agonists have additional benefits for type 2 diabetes besides lower blood glucose… Over 1.4 billion adults were overweight in 2008, and of the 1.4 billion people, 500 million were obese. Obesity is defined as a body mass index >30 g/m2. Also, obesity increases the chance of being diagnosed with …

In the study, sulfonylureas correlated with a significant increase in levels of free fatty acids….

Drug shows a significant reduction in HbA1c in patients with type 2 diabetes… A new investigational drug is underway to help with reduction of HbA1c, weight, and improve glycemic control in type 2 diabetes patients. ITCA 650 is an injection-free GLP-1 receptor agonist that provides continuous subcutaneous exenatide for 12 …

Sulfonylureas not associated with increased cardiovascular mortality, myocardial infarction and stroke in a meta-analysis of 47 randomized clinical trials… Sulfonylureas are relatively inexpensive and are important therapeutic agents in type 2 diabetes management. However, they are not widely used due to safety concerns regarding hypoglycemia and weight gain. Furthermore, it …

GLP-1 analog also showed reduction in weight and incidence of hypoglycemia… Dulaglutide (Trulicity) is a glucagon-like peptide analog that is used once weekly to improve blood glucose level. During the open-label, multinational, parallel arm study, researchers compared the safety and efficacy of dulaglutide 0.75mg and 1.5mg to insulin glargine in …

Program helps aid primary care physicians in the management of patients with diabetes using individualized therapy…. A meta-analysis showed that the most efficacious strategies to improve glucose control were: case management, health care team changes, patient education, and facilitated transmission of patient data to clinicians. Using those 4 key strategies …

Device implantation could be the future in T2DM and weight loss… Weight gain is often a side effect of several different oral antidiabetic drugs (OADs), such as sulfonylureas and thiazolidinedion, along with insulin. Lifestyle modification and weight loss is always recommended in T2DM, but we all know it takes great …