SGLT-2 Therapy Center

Dr. Stanley Schwartz finishes up his slides series on the current state of the obesity epidemic and its relationship with diabetes. Topics covered in this set include a discussion of the newest drug therapies on the market including the incretins and the SGLT-2 inhibitors…. To download in PowerPoint (.ppt) format: Obesity …

Quality issues in the manufacturing plant prevents final approval…. The investigational type 2 diabetes drug empagliflozin won’t win the FDA’s approval until “previously observed deficiencies” at a manufacturing plant are fixed, the drug’s sponsors said last week. Eli Lilly and Boehringer Ingelheim said the FDA had issued a complete response …

Trade group announces 180 diabetes medicines currently in development…. The Pharmaceutical Research and Manufacturers of America (PhRMA) has announced that biopharmaceutical research companies are currently developing 180 new medicines aimed to help those affected by diabetes. Of these drugs in development, 128 of them are indicated for diabetes and 52 …

In this special Homerun Slides presentation, details of the CANTATA-D2 study are reviewed comparing the effects and benefits of the SGLT2 inhibitors and DPP-4 inhibitors…. To download in PowerPoint (.ppt) format: SGLT2 Inhibitors for Treatment of Type 2 Diabetes See more SGLT-2 Resources

But SGLT-2 inhibitors still yield net reduction in plasma glucose, A1C, and weight…. A new class of drugs for type 2 diabetic patients known as sodium-glucose cotransporter 2 (SGLT-2) inhibitors are the latest thing used to reduce plasma glucose levels in the body. The SLGT-2 protein is responsible for about …

How does SGLT-2 inhibitor, ipragliflozon compare to metformin alone?…. Ipragliflozin is an oral medication in development by Astellas Pharma for the treatment of type 2 diabetes. A novel selective sodium glucose co-transporter-2 (SGLT-2) inhibitor, ipragliflozin works similarly to the first in class marketed SGLT-2 inhibitor drug, canagliflozin, by increasing urinary …

Combination well-tolerated in patients with type 2 diabetes…. Ipragliflozin is an oral medication in development by Astellas Pharma for the treatment of type 2 diabetes. A novel selective sodium glucose co-transporter-2 (SGLT-2) inhibitor, ipragliflozin works similarly to the first in class marketed SGLT-2 inhibitor drug canagliflozin by increasing urinary excretion …

Phuong Nguyen, PharmD Candidate, LECOM College of Pharmacy Remarkable as it might sound, the SGLT2 inhibitor drug class arguably dates back 178 years. In 1835, French chemists first isolated a substance known as phlorizin from the bark of apple trees, and in 1886, German physician and early diabetes pioneer Joseph von …

What’s New on the Horizon? Heather Good, Doctor of Pharmacy, Candidate University of Florida Sodium-glucose co-transporter 2 (SGLT2) inhibitors, the first drugs to actually eliminate glucose from the body, are paving the way for a new wave of diabetes treatment options. Canagliflozin (Invokana®) took the U.S. market by storm when …

Phuong Nguyen, Doctor of Pharmacy Candidate, LECOM, College of Pharmacy Studies investigating both mice and humans have shown that chronic hyperglycemia may shift the balance of B-cell proliferation and apoptosis toward cell death, consequently resulting in B-cell deficiency and impaired insulin secretion. Idris and Donnelly (2009) studied the effect of …