Metformin Therapy Center

This is not the first study showing these negative effects of metformin.

Drug said to be possible fix for multiple primary pathophysiologic abnormalities.

Metformin may help lower the risk of cardiovascular events and death in patients with moderate to severe renal function.

We asked the DIC advisory board to comment on the use of metformin in patients who do not have diabetes:
Your patients may have asked about it or, if not yet, they most likely will. What is your comment on whether you recommend metformin for people who do not have diabetes? If you do not, how do you respond to patients who ask about it? If you do, what do you tell your patients? And what do you say to your patients when their other health care providers tell them this is a diabetes drug and they should only be taking it if they have diabetes?
Here's how they responded.

What are the long-term effects of metformin on diabetes prevention?

Metformin and physical activity best prophylactic interventions for prevention.

Treatment throughout pregnancy may reduce rate of miscarriage or preterm delivery.

Metformin proposes therapeutic benefit for HFpEF treatment.

In patients with stage 3 kidney disease, metformin use may be safe and may reduce the risk of mortality and cardiovascular events.

FDA label change warns of increased risk of lactic acidosis in patients with severe renal dysfunction.