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DPP-4 Therapy Center

DPP-4 Inhibitors in Combination with Insulin Therapy for Type 2 Diabetes Patients

The addition of a DPP-4 inhibitor decreased HbA1C while not requiring an increase in insulin, and subjects remained weight neutral without experiencing an increase in hypoglycemic events… Currently approved dipeptidyl peptidase-4 (DPP-4) inhibitors include alogliptin, linagliptin, saxagliptin, sitagliptin and vildagliptin. DPP-4 inhibitors work by enhancing glucose dependent insulin secretion and …

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Metformin Is Best Initial Oral Drug for Lowering Glucose Levels in Diabetes Patients

Metformin, sulfonylureas, thiazolidinedione, and DPP-4 inhibitors were compared to evaluate the effects on the time to subsequent treatment… There are many classes of oral drugs used for diabetes therapy, but there is a lack of evidence as to which drug is best for use as initial therapy. Most patients diagnosed …

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SGLT2 Inhibitors as Add-On for Poorly Controlled Patients on DPP-4s and Metformin

As the diabetes epidemic continues to grow, practitioners are increasingly searching for medication solutions that can help patients to better manage their diabetes. This month, we have a recent slides series from the ADA showing the positive effects of adding-on SGLT-2 inhibitors to the medication regimen of patients on DPP-4’s …

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Handbook of Diabetes, 4th Edition, Excerpt #10: Management of Type 2 Diabetes

handbook-of-diabetes-image

Rudy Bilous, MD, FRCP Richard Donnelly, MD, PHD, FRCP, FRACP   Lifestyle modification The starting points and mainstays of treatment for type 2 diabetes are diet and other modifications of lifestyle, such as increasing exercise and stopping smoking (Figure 11.1). The major aims are to reduce the weight of obese patients and …

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