DPP-4 Therapy Center

Patients are not seeing the expected results because of medication adherence.

Additive glucose-lowering effect of a dipeptidyl peptidase-4 (DPP4) inhibitor and an alpha-glucosidase inhibitor (AGI) might be beneficial in patients with T2DM.

Increased cardio risk of Saxagliptin found during trial prompts FDA decision.

The DPP-IV inhibitor sitagliptin was safe and effective over 3 years for adults aged at least 75 years who had well-controlled type 2 diabetes and cardiovascular disease, findings from an analysis of TECOS study data show.

We know from previous studies that obesity and type 2 diabetes are associated with vascular stiffening and the development of cardiovascular disease.

A DPP-4 inhibitor can help to prevent kidney function and did not have any negative cardiovascular effects.

DPP-4 Inhibitors offer some advantages over existing oral options for the management of type 2 diabetes such as a negligible risk of hypoglycemia compared with sulfonylureas and, in general, a weight-neutral profile.

Forms, dosages and dosing considerations for pregnancy, breastfeeding, hepatic and renal.

Data from 2 trials show long-term use can improve albumin/creatinine ratio, but not other renal outcomes.

Initiation of glucagon like peptide-1 agonists may increase risk of gallbladder or bile duct disease and cholecystectomy; no increased risk associated with DPP-4 inhibitor therapy.