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Diabetes May Be Long-Term Risk Factor for Alzheimer’s Disease-A

Diabetes diagnosis was still strongly associated with Alzheimer’s Disease Diabetes appears to be a long-term risk factor for Alzheimer’s disease (AD) and this risk is not associated with insulin therapy, suggest the results of a 35-year longitudinal study of Israeli men.

The research was presented July 23 at the 8th International Conference on Alzheimer’s Disease and Related Disorders.

Ramit Ravona-Springer, MD, of Sheba Medical Center, Tel-Hashomer, in Ramat Gan, Israel, and colleagues followed Israeli men who were 40 years or older and were participants in a 1963 cardiovascular risk factor cohort study. The men were assessed for diagnosis of dementia in 1999.

The researchers studied 2903 men who were alive in 1999 from the original cardiovascular risk factor cohort of 10,059 men. They assessed the presence of dementia in 1887 subjects, of whom 253 had AD and 1403 had no cognitive impairment. They excluded those with other dementias or mild cognitive impairment.

Among survivors who had diabetes (45 men) 13 (30.2 percent) were diagnosed with AD at follow-up, compared to 15.1 percent of all subjects in the analysis. In a logistic regression analysis, after controlling for age, diabetes diagnosis was strongly associated with AD.
Of 11 men with diabetes who were on hypoglycemic/insulin therapy, three had AD (27.3 percent). In a logistic regression analysis, after controlling for age and hypoglycemic/insulin therapy, diabetes diagnosis was still strongly associated with AD