Type 2 Diabetes

Effect of Sitagliptin on Serum Total Ghrelin Levels in Type 2's

In this study of patients with type 2 diabetes, treatment with sitagliptin was associated with a significant decrease in serum ghrelin levels....

FDA Approves Eli Lilly Diabetes Combo Drug Jentadueto

Boehringer Ingelheim Pharmaceuticals, Inc. and Eli Lilly and Company announced the FDA approved Jentadueto™ (linagliptin/metformin hydrochloride) tablets....

Electronic Health Records Improve Care for Type 2 Diabetes Patients

Use of electronic health records shows promise for improving care and outcomes in patients with type 2 diabetes, but still has considerable room for improvement....

Efficacy and Safety of Bydureon Versus Metformin, Pioglitazone, and Sitagliptin as Monotherapy

In a once weekly injection of exenatide for Drug-Naive Patients with Type 2 Diabetes (DURATION-4) in a 26-week double-blind study they found that exenatide once weekly (EQW) was noninferior to metformin (MET) but not pioglitazone (PIO) and...

A Cost Comparison of a Basal-Bolus Regimen Vs. Premixed Insulin in Type 2's

The study investigated the comparative costs of two different insulin regimens in type 2 diabetes based on data from the GINGER study, which investigated the efficacy and safety of an intensified insulin regimen....

Predicting Kidney Disease in Diabetes Using Tumor Necrosis Factors

According to the results of two 12-year studies, levels of circulating tumor necrosis factor receptor 1 and 2 (TNFR1 and TNFR2) predicts kidney disease in both type 1 and type 2 diabetes....

Weight-Loss Drugs Important in Type 2 Diabetes Management

Optimizing weight "should be a priority" in the management of patients with type 2 diabetes....

Once-Weekly Exenatide Similar to Daily Metformin in Monotherapy for Type 2 Diabetes

A direct comparison of four agents as monotherapy in drug-naive patients with type 2 diabetes shows that exenatide once-weekly, metformin, and pioglitazone provide good improvement in glycemic control, while sitagliptin is less...

Flavonoids Helps to Prevent Heart Disease in Type 2 Diabetic Women

Dietary flavonoids found in foods such as berries and chocolate may reduce the risk of women with type 2 diabetes developing heart disease....

Editor's Note DCMS #67: Adolescents and the Process of Change

It has been said that, "People cannot influence their motivation and actions very well if they do not pay adequate attention to their own performances, the conditions under which they occur, and the immediate and distal effects they produce."...

Diabetes Mellitus 101 for Medical Professionals, PART 4

In this week's Homerun Slides, we continue with Part 4 of our series from Dr. Stanley...

Diabetes Prevention Program Can Deliver Modest Weight Loss

The U.S. Diabetes Prevention Program conducted a clinical trial in 2002 showing that modest weight loss through caloric restriction and increased physical activity reduced the incidence of diabetes in high-risk patients by...

Statins Can Increase Risk of Diabetes

Statin use in postmenopausal women is associated with a significantly increased risk of diabetes mellitus.

Bariatric Surgery Not a Cure for Diabetes

According to Dimitrios Pournaras, MD as reported in the BMJ, "Bariatric surgery (gastric bypass, sleeve gastrectomy, or gastric banding) leads to complete remission in only about one third of patients with type 2 diabetes, and should be...

Weight Loss Is Not The Answer for Preventing Diabetes

Richard Kahn, PhD, who was the chief scientific and medical officer of the ADA for nearly 25 years stated at a conference that, "Community-based weight-loss programs have not been shown to be effective at reducing the incidence of diabetes, so...

How Exercise Benefits Insulin-Treated Obese Patients with Diabetes

Exercise counters adverse CV effects of insulin in overweight/obese patients with type 2 diabetes. Supervised mixed (aerobic and resistance) exercise is effective in improving A1c and cardiovascular disease risk related to insulin treatment in...

Diabetes Mellitus 101 for Medical Professionals, PART 3

In this week's set of Homerun Slides, we discuss whether it is possible to delay the...

Is Engaging in Intense Exercise for Less Time the Answer?

By Sheri Colberg,...

More Years Obese Equals More Diabetes Risk

A longitudinal analysis found that, the longer one has an excessive BMI, the greater the risk of developing type 2 diabetes, but race and young age also are risk factors....

For T2DM, the Quality of Guidelines on Oral Meds Varies Dramatically

According to the results of a systematic review, not all practice guidelines on oral medications for type 2 diabetes are consistent with available evidence, and guideline quality varies widely....

New Early Warning for Type 2 Diabetes

Hebrew University researchers have found the first proof of molecular risk factors for type 2 diabetes that indicate susceptibility to the disease....

United States of Diabetes Report

  You can use the information in this report to provide evidence for your ...

Diabetes Mellitus 101 for Medical Professionals, PART 2

In this week's set of Homerun Slides,...

Weight Loss Improves Beta Cell Function in Type 2 Diabetes

Beta cell function can improve after just 12 weeks of weight loss in patients with type 2 diabetes....

Research Finds That Patients with Diabetes Should Take More Vitamin B12 Daily

People who have type 2 diabetes and are taking metformin should take more than the recommended daily allowance of vitamin B12....

Editor's Note: New Homerun Slides on CVD

Over the past weeks we have shared some great slides on Advanced Glycation End-products, and there's a lot linking these...

Diabetes Mellitus 101 for Medical Professionals, PART 1

This week we begin a new Homerun Slides series on Diabetes Mellitus 101 for ...

Less than a Minute a Day 'Keeps Diabetes Away'

Performing short cycle sprints three times a week could be enough to prevent and possibly treat type 2 diabetes....

GLP-1 Lixisenatide Phase III Results

Adding lixisenatide to metformin and insulin glargine significantly reduced glycated hemoglobin levels and improved post-prandial glucose in patients with type 2 diabetes....

Weight Loss Improves Beta Cell Function in Type 2 Diabetes

Beta cell function can improve after just 12 weeks of weight loss in patients with type 2 diabetes....

Women Working the Night Shift Have a 60% Increased Risk for Diabetes

Women who worked irregularly scheduled night shifts had up to a 60% higher risk of developing type 2 diabetes....

Cutting Calories to 500 per Day Reduces Need for Insulin

Four months of a restricted-calorie diet produced lasting reductions in pericardial fat and improvements in left ventricular diastolic function in a study of obese adults with type 2 diabetes....

Birth Weight Inversely Impacts Diabetes Risk

More weight gain than expected from 48 months to adulthood is tied to impaired fasting glucose, diabetes....

Drinking Alcohol Tied to Lower Diabetes Risk by 30 Percent

Middle aged women who consume large amounts of refined carbohydrates might offset their risk of type II diabetes by drinking a moderate amount of alcohol....

Individualized Management Can Improve Glycemic Control

A collaborative patient-centered approach might improve metabolic control in patients with type 2 diabetes who have a history of poor glycemic control....

Family History Underused in Diabetes Prevention Efforts

Type 2 diabetes prevention programs aimed at high-risk individuals with a family history of the disease may underuse psychological and motivational strategies that emphasize genetic susceptibility....

New Possible DPP-4/TZD Combo for Jan 2012

Takeda announced that the FDA has assigned a Prescription Drug User Fee Act (PDUFA) action date of January 25, 2012 for the review of its investigational type 2 diabetes therapy alogliptin, and the fixed-dose combination therapy...

New Study Supports Cardiovascular Safety of Bristol-Myers Squibb/AstraZeneca's SGLT2 Drug Dapagliflozin in Type 2's

Dapagliflozin, an inhibitor of SGLT2 as an adjunct to diet and exercise, is being investigated to evaluate its safety and its efficacy on blood sugar levels in adults with type 2 diabetes....

Tight Glycemic Control Won't Cut Diabetes Patients' Heart Failure Risk

Intensive blood glucose control won't reduce the risk of heart failure in patients with type 2 diabetes -- and tight control using a thiazolidinedione may actually increase the risk....

Free Screenings Can Show One in Four Has Hidden Prediabetes or Diabetes

Free screening by trained volunteers can pick up cases of dysglycemia and other diabetic conditions in the general population....

Diabetes Drug Also Reduces Inflammation

A GLP-1 drug prescribed to help patients with type 2 diabetes improve blood-sugar control also has a powerful anti-inflammatory effect, and the effect was observed within 2 hours following a single dose....

Pyridoxamine May Slow Early Diabetic Nephropathy

Pyridoxamine (vitamin B6) is known to be an effective scavenger of reactive oxygen species and a potent inhibitor of advanced glycation end products. A new study demonstrated the benefits for patients with Type 2...

Aerobic Exercise and Quality of Life for Type 2 Diabetes Patients

Eight-week aerobic exercise program had a major impact on fasting blood sugar, HbA1c, high-density lipoprotein, low-density lipoprotein, and quality of life in patients with type 2 diabetes....

Insulin Sensitizers Limit Muscle Loss in Older Diabetes Patients

Insulin sensitizers may limit the muscle loss seen in elderly men with type 2 diabetes....

Natural Enzyme Has Potential to Reverse Type 2 Diabetes

A natural compound found in the body, called nicotinamide mononucleotide, or NMN, is found to help restore normal blood sugar metabolism....

Three Questions Show Type 2 Diabetes Risk

A simple, three-item instrument may be enough to accurately identify those individuals who are at high risk for type 2 diabetes in the next five years....

Higher HDL Lowers CVD Risk in Type 2 Diabetes

Higher HDL levels in patients with type 2 diabetes significantly reduced the odds of hospitalization related to cardiovascular disease....

Elevated Liver Function Enzymes Tied to Diabetes Risk

High alanine aminotransferase, γ-glutamyl transferase may predict risk of type 2 diabetes....

Men Develop Diabetes with Less Weight Gain than Women

  Men apparently develop type 2 diabetes with less weight gain than women a finding that may help explain why men have higher rates of diabetes in many parts of the world....

Liver Function Tests (LFTs) Often Miss Liver Disease in Type 2 Diabetes

Conventional liver function tests may miss a diagnosis of nonalcoholic fatty liver disease in patients with type 2 diabetes....

Oral Health Lacking for Diabetes Patients

Poor oral health can lead to a greater risk of developing complications from type 2 diabetes, and problems such as inflammation from swollen gums can make diabetes worse, as well as having a negative impact on cardiovascular disease and...

Tight Control No Help for Cognitive Loss in Diabetes

Tight glucose control won't mitigate the cognitive effects of type 2 diabetes, an ACCORD subanalysis found....

Salsalate Improves Glycemic Control in Newly Diagnosed Type 2's

The results show that salsalate is effective in improving glycemic control in newly diagnosed naive patients with type 2 diabetes....

EASD: Intensified Treatment with Basal Insulin Improves Control and Weight Loss

Adding insulin detemir to a treatment regimen of metformin and liraglutide improved glycemic control and led to sustained weight loss for up to 52 weeks in patients with type 2 diabetes....

EASD: 'Gliptin's' May Be Heart Savers

While searching for potential cardiovascular risks among studies involving dipeptidyl peptidase-4 (DPP-4) inhibitors in type 2 diabetes patients, researchers made a surprising discovery –- treatment with the so-called gliptin class...

New First in Class Glucagon Antagonists Show Promise for Diabetes

New data on two investigational glucagon receptor antagonists suggest that this novel class of drugs has potential to be an effective treatment for type 2 diabetes....

EASD: Elevated Glucose Appears Years before Diabetes Diagnosis

  In patients diagnosed with type 2 diabetes, elevations in blood levels of glucose and glycated hemoglobin (HbA1c) can be seen as much as 10 years prior to diagnosis....

EASD: Biomarkers May Predict CAD, Death in Diabetes Patients

Two biomarkers may be associated with cardiovascular events and death in type 2 diabetes patients, researchers reported at EASD....

EASD: No Microvascular Benefit with Intense BP, Glucose Control

Aggressively lowering blood pressure and blood glucose together won't provide any microvascular benefits to type 2 diabetes patients, researchers said....

Miglitol Increases GLP-1 Levels for Patients Treated with Sitagliptin

Miglitol administered before breakfast increased plasma active glucagon-like peptide-1 (GLP-1) levels after lunch in patients with type 2 diabetes treated with sitagliptin....

EASD: First Injection-free Once-A-Year GLP-1

ITCA 650, injection-free continuous delivery of GLP-1 therapy, demonstrated significant and sustained reductions in HbA1c and body weight over 48 weeks of treatment with a marked reduction in the GI AEs typically associated with this...

EASD: Poor Glucose Control in Diabetics Predicts Heart Failure

A new nationwide analysis of glucose management in type 2 diabetes suggests that poor glucose control is a strong predictor of heart failure....

EASD: Twice-Daily Aspirin Betters Platelet Inhibition for People with Diabetes

Twice-daily aspirin administration, but not a once-daily doubling of the dose, appears to provide good inhibition of platelet cyclooxygenase (COX)-1 in diabetic patients who have rapid recovery of COX-1 activity, and might enhance...

EASD: Having Diabetes and Feeling Bad Add Up to Shorter Life

Men with type 2 diabetes and an acute myocardial infarction who score lower on quality-of-life measures have a greater mortality risk than other men with these conditions whose scores indicate they feel better about their health,...

How Long a Person Is Overweight May Decide their Diabetes Risk

Being obese might up the chance of developing Type 2 diabetes, but the true risk factors may lie in how much someone is overweight and how long they've been that way. This is crucial information because we are seeing more obesity in young...

Newly Diagnosed Type 2 Initiated on Basal Insulin with Oral Antidiabetic Med

In newly diagnosed type 2 diabetes, therapy with oral antidiabetes drugs plus basal insulin (OAD+insulin) has had favorable outcomes on recovery and maintenance of β-cell function and protracted glycemic remission compared to...

Physical Inactivity Linked to Type 2 Diabetes

Physical inactivity may play a key role in the development of Type 2 diabetes, according to new research....

Value of Intensive Treatment for Early Diabetes Questioned

When early type 2 diabetes is detected by screening, intensive management doesn't seem to cut the risk of certain complications later on, a Danish study indicates....

Fat Disrupts Sugar Sensors Causing Type 2 Diabetes

US researchers say they have identified how a high-fat diet interferes with the body's sugar sensors and triggers type 2 diabetes....

High Dairy Intake in Teens May Reduce Diabetes Risk by 38 Percent

New research has shown eating plenty of dairy foods as a teenager may reduce the risk of developing type 2 diabetes during adulthood....

Two Steps to Predict Future Risk for Type 2 Diabetes

A 2-step model helps predict future risk for type 2 diabetes, according to the results of a validation study....

Diabetes Patients Who Lose Weight Can Improve Erectile Function and Libido

A new study explains that improved erectile function, sexual desire and lower urinary tract symptoms are enhanced by weight loss in obese men with type 2 diabetes....

New Technology Helps Patients Manage Diabetes

An interactive computer software program appears to be effective in helping patients manage their Type 2 diabetes using their mobile phones, according to a new study....

Dietary Fish Linked to Lower Risk for Type 2 Diabetes in Men

Dietary fish consumption is linked to a lower risk for type 2 diabetes in men but not in women, according to the results of a prospective study....

Physical Activity by Women at High Risk of Diabetes

Women should get at least 150 minutes of physical activity each week to help reduce their risk of developing type 2 diabetes....

New Target Shows Promise for Type 2 Diabetes

An investigational first in class compound with a novel mechanism of action appears to improve glycemic control in type 2 diabetes....

Replace Nuts for Carbs Beneficial in Diabetes

Eating nuts every day could help control Type 2 diabetes and prevent its complications....

Exenatide Reduced Heart Failure Risk by 50 Percent in Type 2's

Data from a retrospective analysis have demonstrated a reduction in the probability for patients with type 2 diabetes to develop heart failure when adding exenatide injection to current treatment. The reduction was particularly noted in...

Sitagliptin Shows Anti-inflammatory Activity in Diabetes Patients

  The dipeptidyl peptidase (DPP)-4 inhibitor sitagliptin exerts an anti-inflammatory effect in patients with type 2 diabetes at the cellular and molecular level....

New Target Shows Promise for Type 2 Diabetes

An investigational compound with a novel mechanism of action appears to improve glycemic control in type 2 diabetes....

Targeting Postprandial Versus Fasting/Premeal Glycemia More Effective in Reducing Cardiovascular Risk

Older type 2's improve cardiovascular risks when using insulin and targeting postprandial versus fasting glycemia....

Experimental TZD Balaglitazone Shows Fewer Side Effects

  Balaglitazone, an experimental thiazolidinedione derivative, was slightly less effective than pioglitazone but had fewer side effects in patients with type 2 diabetes in a recent phase III trial....

Osteoarthritis Drug Diacerein Improves Glycemic Control in Type 2 Diabetes

In a study, two months of treatment with the anti-inflammatory agent diacerein improved insulin secretion and dropped A1C levels in type 2 diabetes patients from 8.3% to 7.0%, within 60 days....

Mutations in the Skin Barrier Correlate with Increased Type 2 Diabetes Risk

Defective skin barrier function, as evidenced by common filaggrin mutations, may predispose patients to type 2 diabetes....

Omega-3 Fats Tied to Lower Diabetes Risk

People who get plenty of omega-3 fatty acids in their diets may have lowered odds of developing type 2 diabetes, two new reports suggest....

More Information Showing Dapagliflozin Improves Glycemic Control

Dapagliflozin significantly improved glycemic control and was well tolerated among treatment-naïve patients with type 2 diabetes and those unresponsive to prior treatment with glimepiride or metformin....

Sanofi's Once Daily GLP-1 Lyxumia ® Meets Primary Endpoint in Phase 3 Study

Lyxumia (lixisenatide) when used as an add-on therapy to basal insulin (in association with or without metformin), achieved its primary efficacy endpoint of significantly reducing HbA1c versus placebo for patients with type 2 diabetes...

Low Glycemic Diet More Effective than Low Fat Diet in Reducing HbA1c in Obese T2DM Patients

A glycemic- rather than a fat-targeted dietary regimen may be more effective in lifestyle modification programs for obese T2DM patients....

Scientists Discover 'Ultra-Bad' Cholesterol

Study of super-sticky LDL may spur new heart disease treatments for seniors with type 2 diabetes....

Risk Factors for the Development of Albuminuria and Renal Impairment in Type 2 Diabetes

Distinct sets of risk factors were associated with the development of albuminuria and renal impairment consistent with the concept that they are not entirely linked in patients with type 2 diabetes....

FDA Pulls Diabetes Drug Avandia from Drug Stores

The controversial diabetes drug Avandia, known generically as rosiglitazone, will no longer be available in most pharmacies after November....

New Study Pushes to Expand 'Prediabetes' Label

Having normal blood sugar levels is no guarantee against developing type 2 diabetes down the road, according to researchers. What should we do with a person with a fasting blood sugar on the higher end of normal between 91-99 mg/dL who has...

Growth Hormone Treatment Linked to Diabetes in Children

Type 2 diabetes is eight and a half times more common among children in the US treated with growth hormone than among kids who are not on the hormone treatment....

Benefits of Modest Weight Loss in Improving Cardiovascular Risk Factors in Type 2 Diabetes

Overweight and obese individuals are encouraged to lose 5–10% of their body weight to improve cardiovascular disease (CVD) risk, but data supporting this recommendation are limited, particularly for individuals with type 2...

Preventing Type 2 Diabetes with Early Pharmacological Intervention

According to Ralph DeFronzo, it is never too early to prevent diabetes....

Diabetes Poses Less Cardio Risk for Women

In a study of asymptomatic patients with type 2 diabetes, women had a lower cardiac event rate than men, although screening for silent myocardial ischemia did not benefit either sex....

Low-Dose Aspirin Helps Heart Only in Some Diabetes Patients

Low-dose aspirin is predominantly of value in reducing atherosclerotic events in patients with less advanced diabetes....

Diet Soft Drinks Not Linked to Type 2 Diabetes

New research demonstrates that the consumption of diet soft drinks is not associated with an increased risk of type 2 diabetes....

'Master Regulator' Gene Behind Obesity, Diabetes Identified

Researchers have found that a gene linked to type 2 diabetes and cholesterol levels is in fact a 'master regulator' gene, which controls the behavior of other genes found within fat in the body....

Colesevelam an Effective Add-on Therapy in Type 2 Diabetes

Colesevelam (Welchol,) might not be a first choice for many clinicians in the treatment of type 2 diabetes; however, a post hoc analysis of 3 large randomized controlled trials reveals that it might be a good option as an add-on therapy f...

Structured Exercise Controls Blood Sugar

Structured exercise programs comprising aerobics, resistance training or both helps people with Type 2 diabetes control blood sugar levels, and although physical exercise advice by itself does not appear to make any difference, when...

Cell Phones Keep Blood Pressure and Diabetes in Check

A mobile-phone-based remote patient monitoring system helped patients with Type 2 diabetes and uncontrolled hypertension get their blood pressure (BP) under control....

Study Helps Clarify Link between High-Fat Diet and Type 2 Diabetes

New research adds clarity to the connection that saturated fatty acids but not the unsaturated type can activate immune cells to produce an inflammatory protein, called interleukin-1beta....

FDA Approves New DPP-IV Inhibitor: Tradjenta (Linagliptin)

A new prescription medication Tradjenta (linagliptin) has gained FDA approval for the treatment of adult Type 2 diabetes. Tradjenta will compete with two other drugs in the same family, Onglyza and Januvia....

Self-Monitoring Eases Doctors' Reluctance to Start Insulin

Glucose monitors and at-home record-keeping improved outcomes for orally managed diabetics with poorly controlled disease -- by prompting their doctors to put them on insulin faster....

Hyperglycemic Emergencies

Lana Kravarusic Doctor of Pharmacy Candidate, University of Florida 

Essential Oils for the Management of Type 2 Diabetes

Ivory A. Gordon, Pharm.D....

Testosterone Gel Improves Diabetes in Men with Low Levels

News from the British Endocrine Society meeting  MANCHESTER, England -- Topical testosterone replacement reduced insulin resistance and glycated hemoglobin in men who were deficient in the hormone and at ...

How to Easily Reap the Health Benefits of Physical Activity

By

Get Your Kids Moving, Too

Oprah's Outpouring: A Bittersweet Commentary on Responses to Her Diabetes Show

Theresa Garnero, APRN, BC-ADM, MSN,...

America's Silent Killer: Oprah and Dr. Oz Want to Save Your Life

By...

The 30 Day Challenge

Combination Therapy: Oral medications during the day and Lantus at night

Being Female and Athletic: Special Concerns for Diabetic Women Only

If your patients are female, past puberty, and still young enough to be menstruating, then you’ll want to read what Sheri Colberg, Ph.D., FACSM, has to say in this week’s feature; Being Female and Athletic: Special Concerns for Diabetic...

New Perspectives In Oral Care For Those With Type 1 And Type 2 Diabetes

Charles W. Martin, DDS, founded DentistryForDiabetics, a nationwide group of dentists committed to helping those with diabetes. He authored the book Don’t Sugarcoat it: The Story of Diabetes and Dentistry and we are happy that he has joined...

New Test For Diagnosis of Diabetes and Pre-Diabetes

The ADA and other organizations will be announcing the guidelines on how to use the A1c test to diagnose diabetes. The test that has been used by most doctors is the fasting blood glucose test. The problem with the fasting blood glucose is that...

Recent Advances in GLP-1 Receptor Agonists in the Treatment of Type 2 Diabetes

A couple of months ago we had a review of GLP-1 mimetic therapies and studies form the European Association for the Study of Diabetes (EASD) 44th Annual Meeting convened in Rome, Italy, September 8-11, 2008. Many of you emailed me asking for more...

Your First Year with Diabetes: What to Do, Month by Month

For the past 5 years Theresa Garnero, APRN, BC-ADM, MSN, CDE, has brought us some great laughs with her diabetes cartoons. But all those letters after her last name also means she knows something about diabetes care. She has just completed the book...

HIV-infected patients are at an increased risk for developing Diabetes

More and more patients with HIV are controlling their disease well. When viral loads are under control, patients often are seen by clinicians for other problems. Diabetes seems to be one of those problems that get a lot of attention. My current...

Preteens, teens doubled use of diabetes drugs

A recent article in Pediatrics, discussed how preteens and teens have doubled use of diabetes drugs in the past 4 years and that the prevalence is dramatically higher among young girls vs. boys. Why is this occurring? Why is it higher in girls?...