Brown Adipose Tissue Holds Weight Loss Potential
Researchers from Sweden have demonstrated that brown cells as well as "brite" cells exist in the neck region in adult humans. The "classical" brown fat tissue, common in newborns but previously not thought to be present in...
How Type 2 Diabetes Develops
New mouse model shows how type 2 diabetes might develop....
Type 1 Diabetes Triggered by Animal Infection?
Study shows peaks and clusters of type 1 diabetes, paralleling viral patterns....
Increases in an Inflammatory Protein Leads to Heart Disease
An inflammatory protein, calprotectin, links hyperglycemia to myelopoiesis and the increase risk of coronary heart disease....
Hormone from Fat May Play Key Role in the Treatment of Type 2 Diabetes
Elevated levels of a hormone released from adipose tissue may be the key link in the development of type 2 diabetes in obese patients....
Low Melatonin Doubles Diabetes Risk
The evidence for a link between the body clock hormone melatonin and type 2 diabetes continues to mount....
Cells That Increase Fat Burning Found in Humans
The find is crucial for fat research and future treatment of obesity....
Discovery Raises Hope for Type 1 Diabetes Reversal
A two-step process consisting of one drug to induce immune tolerance and another to promote islet regeneration could be key to type 1 diabetes reversal....
Hair Cortisol Predicts CVD in Seniors
The risk of cardiovascular disease (CVD) among those with higher levels of cortisol in their hair was similar to the risk associated with hypertension or obesity....
Leptin Gene Therapy Possible New Option in Treating Diabetes and Obesity
Leptin therapy studies are looking very promising for the treatment of diabetes in both type 1 and 2 patients....
Excess Glucose May Harden Heart and Lungs
Research found that glucose suppressed ferroelectricity up to 50%....
New Pill in the Works for Type 1 Patients
Protein that lowers blood sugar may be new oral diabetic agent for type 1 patients....
Lack of Co-enzyme 10 May Increase Risk of Diabetes with Statin Use
Possible use of co-enzyme 10 to reduce this risk is being considered....
Diabetes Vaccine
"Bacillus-Calmette-Guerin vaccine may cause TNF release to destroy autoimmune cells attacking the pancreas."...
Antibody Treatment for Diabetes under Evaluation
HbA1c and fasting glucose were reduced following injection of an antibody against the cytokine LY2189192....
Obesity without Health Problems: A New Inflammatory Marker Discovered
A marker called AIM (apoptosis inhibitor of macrophage) is an important factor in the autoimmune process. The inhibition of AIM may stop the body from producing antibodies which attack the self....
Psoriasis Tied to Increased Risk of New-Onset Diabetes
Researchers found that even those with mild symptoms of psoriasis face a significant risk for diabetes. They analyzed data from a populational cohort of participants 10 years of age or older in January 1997 and followed through December 2009. Of...
High Carbohydrate Consumption During Infancy Has Long-standing Effects
In an animal study, high-carbohydrate intake after birth led to detrimental long-term effects….
Brown Fat Production Mechanism Discovered
Brown fat plays an important role in diabetes and metabolism because of its ability to metabolize glucose and fatty acids....
Reduction in A1c Relates to Decreases in hs-CRP
Poorly controlled type 2 diabetes patients with self-monitoring of blood glucose protocol have been shown to decrease high-sensitivity C-reactive protein levels....
Alcohol Changes Brain Responses to Glucose and Insulin
Rats given large alcohol doses to simulate a 3-day bender developed abnormal brain responses to glucose and insulin resistance, which lasted for days after the alcohol wore off. Inflammation in the hypothalamus...
Adiposity, Hyperglycemia Tied to Cognitive Performance
Researchers examined the correlation between markers of insulin resistance, markers of adiposity, HbA1c, and cognitive performance in a sample of 1,172 adults aged 35 to 64 years without diabetes. In tests...
Calcium Supplements May Increase Risk of CVD Death
A high intake of supplemental calcium appears to be associated with an increased risk of CVD death in men but….
Mechanism that Links Diabetes and Obesity with Cancer Discovered
Sustained high levels of sugars damage our cells and can….
Low Adiponectin in First Trimester Linked to GDM
Also linked to insulin resistance regardless of adiposity or glycemic measurement....
Bile Acid Sequestrant Reduces Glucose Concentration in T2DM
For type 2 patients on metformin monotherapy, the bile acid sequestrant colesevelam reduces fasting and postprandial glucose concentrations without any effects on....
Women Have to Do 20% More than Men
Women have to do about 20% more exercise to get the same benefits….
Type 1 Children Not Meeting Targets
Less than a third of youth with type 1 diabetes are meeting recommended A1c targets....
Alzheimer's Linked to Diabetes
Both type 1 and type 2 diabetes have been linked to cognitive problems like Alzheimer's disease and dementia....
Novel Racial/Ethnic Differences Found in Diabetic Kidney Disease
Minorities more likely to have proteinuric DKD; less likely to have nonproteinuric DKD....
Different Sugars Have Different Effects
Glucose appears to temper brain activity in regions that regulate appetite and reward but fructose does not....
Enzymes for Prediabetes
Two enzymes that are elevated in prediabetes could hold clues to helping the 79 million Americans with the condition avoid serious vascular complications and even identify those most at risk for full-blown diabetes....
Landmark Discovery on How Insulin Works Could Lead to New Insulins
For the first time, researchers have captured the intricate way in which insulin uses the insulin receptor to bind to the surface of cells....
Pancreas Size a Marker for Diabetes
The smaller pancreas that is often found in patients with type 1 diabetes was also seen in people at risk for the disease, pointing to a possible diabetes biomarker....
Clue Provides New Piece of the Diabetes Puzzle
Researchers show that the cells that produce glucagon are stimulated by the hormone itself. A previous study by the same group demonstrated that this principle also applies to insulin....
New Treatment Reduces Weight 10 Percent and Improves Insulin Sensitivity
A new, lab-created antibody that mimics the action of a naturally occurring molecule causes weight loss....
How the Liver Affects Insulin and Vice Versa: Part 1 Carbohydrate Metabolism
Dave Joffe, Editor-in-chief, Diabetes In Control
Andre McMahon, Ben Mitrano, PharmD Candidates, University of Florida College of...
Stem Cell Breakthrough May Bring Us Closer to a Cure
In a breakthrough that signifies a move toward a cure for type 1 diabetes, Australian researchers have identified stem cells in the pancreas that can be turned into insulin-producing cells....
New Study Demonstrates Low-Carb Diets Reduce Risk for Heart Disease and Inflammation
When overweight or obese people lose weight, using a low carb diet, they can have a significant reduction in inflammation throughout their body, as measured by three common markers....
Insulin Sensitivity Highest after Breakfast
Increased beta-cell responsiveness to glucose, disposition index; lower hepatic insulin extraction tends to be higher after breakfast....
Diabetes with Psoriasis Increases Vascular Risk
Patients with diabetes and psoriasis are significantly more likely to develop new-onset, diabetes-related microvascular and macrovascular complications than are psoriasis-free patients with diabetes....
Peptide Predicts Diabetes, CV Disease in Women
High levels of the peptide proneurotensin are associated with an increased risk of diabetes, cardiovascular disease, and death in women, but not necessarily in men....
EASD: Findings Presented on New Insulin Sensitizing Agent for Treatment of Type 2 Diabetes
Researchers have identified a mitochondrial target through which insulin sensitizers achieve their anti-diabetic effects....
Diabetes Cause Linked to Iron
Researchers at the University of Copenhagen, in conjunction with those at Novo Nordisk A/S, have presented a new concept concerning the cause of diabetes which is linked to iron and how it causes beta cell death....
Absence of Certain Proteins Causes Diabetes, and Rheumatoid Arthritis
The absence of related protein molecules, Puma and Bin, prompts immune cells to turn against human organs they are meant to protect and cause type 1 diabetes and rheumatoid arthritis....
Fructose and Sugar Substitutes Alter Gut Microbiota Increasing Risk of Metabolic Disorders
Changes in host-microbe interactions may lead to development of metabolic disorders and obesity....
Psoriasis Increases Risk of Diabetes
A new study of the entire Danish population confirms previous reports of increased risk of diabetes mellitus in patients with psoriasis, and shows the risk increases with the severity of psoriasis....
Saliva and Tears an Indicator of Diabetes
Researchers from Purdue University recently announced that they have developed a new type of biosensor for diabetes testing that detects glucose in saliva, tears, and urine....
Faustman's Type 1 Diabetes Cure Raises Debate
Dr. Denise Faustman's announcement of the results of a small study of a handful of type 1 patients showing the regeneration of beta cells with the use of a TB vaccine that has been available for years is causing a controversy in the medical...
TB Vaccine a Possible Breakthrough to Treat Type 1 Diabetes
Study found vaccine triggered death of rogue immune-system cell, and beta-cells kicked in....
Newly Discovered Diabetes Molecule Causes increased Microscopic Stress
At its most fundamental level, diabetes is a disease characterized by stress — microscopic stress that causes inflammation and the loss of insulin production in the pancreas, and system-wide stress due to the loss of that...
Endurance Training Cuts Lipid-Induced Insulin Resistance
Endurance training seems to lessen the effect of lipid-induced insulin resistance, specifically by preventing lipid-induced reduction in nonoxidative glucose disposal (NOGD)....
New Method of Identifying Molecules Could Help to Prevent Diabetes
Method discovers a de-synchronization of insulin secretion which is the first measurable sign in people suspected of developing type 2 diabetes....
High Plasma Bicarbonate Levels Tied to Lower Diabetes Risk
Women with high plasma levels of bicarbonate were at decreased risk for developing type 2 diabetes....
Chemicals in Nail Polish, Hair Sprays Tied to Increased Diabetes Risk
A study lead by researchers from Brigham and Women's Hospital (BWH) shows an association between increased concentrations of….
New Way to Treat Diabetes – Treat the Biological Clock
Biologists at UC San Diego have discovered a chemical that offers a completely new and promising direction for the development of drugs to treat metabolic disorders such as type 2 diabetes....
Cholecalciferol Preserves Beta-Cell Function in Type 1 Patients
In a small randomized trial, cholecalciferol helped preserve beta-cell function in patients with new-onset type 1 diabetes....
Incretin Effect Independent of Glycemia Level
Healthy individuals without diabetes have similar increases in insulin secretion....
Injured Brains Repaired with Metformin
Metformin might offer a therapy for nervous system damage....
Hormone Discovered That Preserves Insulin Production and Beta Cell Function in Diabetes
Duke University Medical Center researchers have found protective, anti-diabetic functions for a hormone that, like insulin, is produced by the islet cells of the pancreas....
Apolipoproteins Can Be Biomarkers for Diabetic Retinopathy
Serum apoliproteins are linked to markers of systemic, retinal microvascular dysfunction in diabetes....
Psoriasis May Increase Risk of Diabetes
Psoriasis, especially more severe cases, may raise the risk of developing diabetes, a population-based study determined....
Cold Burns Fat and Reduces Obesity
A type of "good" fat found in the body, which helps burn calories, can be activated by cold temperatures. Can cooling vests be the answer to preventing type 2 diabetes?...
High Fructose Consumption Impairs Liver Function
Obese patients with type 2 diabetes who increased their habitual dietary fructose consumption experienced reduced hepatic adenosine triphosphate concentrations....
Fatty Liver Disease in Diabetes: Good and Bad?
When the enzyme called histone deacetylase 3 (HDAC3) was removed, the mice had massively fatty livers, but lower blood sugar, and were thus protected from glucose intolerance and insulin resistance....
Possible Protective Blood Factors against Type 2 Diabetes Found
Researchers have shown that levels of certain related proteins found in blood are associated with a greatly reduced risk for developing type 2 diabetes up to a decade or more later....
Shift Work with Less Sleep Sets Stage for Diabetes
Short sleep on a disrupted schedule -- common in shift work -- significantly increases blood sugar, setting the stage for obesity and diabetes....
Sugar Production Switch in Liver Offers New Target for Diabetes Therapies
In their extraordinary quest to decode human metabolism, researchers at the Salk Institute for Biological Studies have discovered a pair of molecules that regulates the liver's production of glucose....
AACE Endorses New Lower LDL Targets and ApoB Testing
New guidelines on dyslipidemia and the prevention of atherogenesis give official sanction to something endocrinologists have been doing for years: lowering LDL targets....
Three Independent Factors Increase Diabetes Risk
Insulin resistance, overweight/obesity, and fatty liver commonly occur together but are independently associated with an increased risk of developing type 2 diabetes....
Diet Soda May Increase Glucagon-Like Peptide 1 Levels
The increase was seen in healthy youths and those with type 1 diabetes, but not in those with type 2 diabetes....
H. Pylori Linked to Diabetes Marker
The bug that causes ulcers may also play a role in the development of type 2 diabetes....
High A1c in Some Subjects May Not Indicate Prediabetes
A new study has shown that for people with iron-deficiency anemia, elevated A1c's may not reflect glycemic parameter....
Insulin Production Persists Decades after Diagnosis of Type 1 Diabetes
C-peptide production and beta cell functioning is detected decades after disease onset, which may contribute to the growing body of evidence suggesting there might be a longer window for therapeutic intervention....
Shorter Arm Length Linked to Type 2 Diabetes
People with shorter arm length are at higher risk for type 2 diabetes....
Insulin as a Satiety Signal in Postprandial Period
Brain insulin may act as a satiety signal during the postprandial period and is associated with decreased appetite and reduced intake of highly palatable food....
Diabetes May Start in the Intestines
Scientists have discovered that problems controlling blood sugar may begin in the intestines....
Protein's Role In Obesity, Diabetes and Aging
Researchers at Washington University School of Medicine in St. Louis have identified a potent regulator of sensitivity to insulin....
Mediterranean Diet Associated with Reduced Small Vessel Damage in the Brain
Consumption of a Mediterranean-style diet is associated with a reduced burden of white matter hyperintesity volume, a marker of small vessel damage in the brain....
Brown Fat, Triggered by Cold or Exercise, Yields the Key to Weight Control
Fat people have less than thin people. Older people have less than younger people. Men have less than younger women....
Ulcer-causing Bacteria Linked to Higher Diabetes Risk
People who have been infected with the ulcer-causing bacteria Helicobacter pylori are more than twice as likely to develop diabetes later on as people who do not have signs of the infection....
The Pancreas Also Has Taste Buds
Pancreas can taste fructose, hinting at links to diabetes....
Gene Study Sheds Light on Body Clock's Link to Diabetes
A mutation affecting a sleep-wake hormone may disrupt blood sugar control....
New Information on Link between 'Killer Cells' and Diabetes
Our own killer T-cells in the human body which help protect us from disease may inadvertently destroy cells that produce insulin....
Stem Cell Therapy May Reverse Diabetes
An immune regulator from healthy cord blood stem cells (CB-SCs) can "educate" the T cells of a person with type 1 diabetes, enabling the pancreas to produce insulin....
Intranasal Insulin Boosts Cognitive Function
Pooled data suggest that intranasal insulin may have a positive effect on cognition in both impaired and normal subjects....
Editor's Note: "Schiff base" and AGEs
Some of you may remember the term "Schiff base" from your days in the chemistry lab, but do you have any idea what this compound has to do with diabetes? When it comes to advanced glycation end products (AGEs), a Schiff base is what...
GLP-1's Function in Preserving B-cells
Associations between acute glucose lowering and improved acute insulin secretory responses suggest improved β-cell function. Comparing and assessing effects of pharmacological therapies used to control hyperglycemia on β-cell...
Test Your Knowledge #599: Which of the following abnormalities relating to the incretin pathway...
Which of the following abnormalities relating to the incretin pathway and renal glucose reabsorption are seen in patients with diabetes?
How the Liver Affects Insulin and Vice Versa: Part 2, Obesity and Lipid Metabolism
Andre McMahon, PharmD Candidate, University of Florida College of Pharmacy
Dave Joffe, Editor-in-chief, Diabetes In...
Overview of AGEs, Part 2 of 4
In this week's set of Homerun Slides, we review AGEs and their relation to...
Overview of AGEs, Part 1 of 4
This week we begin a new Homerun Slides series on advanced glycation end-products (AGEs)...
Robert Stanton, MD: High Protein Diets and Kidney Disease
Dr. Robert Stanton explains how all the studies on low/high...
Evan Sisson, PharmD, Q2: How Has the Definition of the "Right" Level for LDL Changed?
Evan Sisson discusses how researchers are getting closer to an...
Laura Shane-McWhorter, PharmD, Q3 The Benefits of Fiber
Professor Shane-McWhorter gives us a quick medical overview of...
Dr. Gregory Frost Introduction
Dr. Frost introduces himself to us and talks about Halozyme, and how...
Dr. Gregory Frost Q1 What Is Halozyme's Current Focus?
Dr. Frost talks about the background and history of Halozyme's...
Dr. Gregory Frost Q2 Who Participated in the Study and How Did They Do?
Dr. Frost goes over some of the details of the Halozyme study...
Dr. Gregory Frost Q3 Possible Breakthrough with an Insulin Additive
Dr. Frost talks about the results of the Halozyme study and the...
Peter Nilsson, MD, PhD, Q2: What Do You Want Your A1c to Be?
Dr. Nilsson gives us several options for the "best" A1c,...
