Pathology

Fatty Liver Disease in Diabetes: Good and Bad?

When the enzyme called histone deacetylase 3 (HDAC3) was removed, the mice had massively fatty livers, but lower blood sugar, and were thus protected from glucose intolerance and insulin resistance....

Possible Protective Blood Factors against Type 2 Diabetes Found

Researchers have shown that levels of certain related proteins found in blood are associated with a greatly reduced risk for developing type 2 diabetes up to a decade or more later.... 

Shift Work with Less Sleep Sets Stage for Diabetes

Short sleep on a disrupted schedule -- common in shift work -- significantly increases blood sugar, setting the stage for obesity and diabetes....

Sugar Production Switch in Liver Offers New Target for Diabetes Therapies

In their extraordinary quest to decode human metabolism, researchers at the Salk Institute for Biological Studies have discovered a pair of molecules that regulates the liver's production of glucose....

AACE Endorses New Lower LDL Targets and ApoB Testing

New guidelines on dyslipidemia and the prevention of atherogenesis give official sanction to something endocrinologists have been doing for years: lowering LDL targets.... 

Three Independent Factors Increase Diabetes Risk

Insulin resistance, overweight/obesity, and fatty liver commonly occur together but are independently associated with an increased risk of developing type 2 diabetes....

Diet Soda May Increase Glucagon-Like Peptide 1 Levels

The increase was seen in healthy youths and those with type 1 diabetes, but not in those with type 2 diabetes....

H. Pylori Linked to Diabetes Marker

The bug that causes ulcers may also play a role in the development of type 2 diabetes....

High A1c in Some Subjects May Not Indicate Prediabetes

A new study has shown that for people with iron-deficiency anemia, elevated A1c's may not reflect glycemic parameter....

Insulin Production Persists Decades after Diagnosis of Type 1 Diabetes

C-peptide production and beta cell functioning is detected decades after disease onset, which may contribute to the growing body of evidence suggesting there might be a longer window for therapeutic intervention....

Shorter Arm Length Linked to Type 2 Diabetes

People with shorter arm length are at higher risk for type 2 diabetes....

Insulin as a Satiety Signal in Postprandial Period

Brain insulin may act as a satiety signal during the postprandial period and is associated with decreased appetite and reduced intake of highly palatable food....

Diabetes May Start in the Intestines

Scientists have discovered that problems controlling blood sugar may begin in the intestines....

Protein's Role In Obesity, Diabetes and Aging

Researchers at Washington University School of Medicine in St. Louis have identified a potent regulator of sensitivity to insulin....

Mediterranean Diet Associated with Reduced Small Vessel Damage in the Brain

Consumption of a Mediterranean-style diet is associated with a reduced burden of white matter hyperintesity volume, a marker of small vessel damage in the brain....

Brown Fat, Triggered by Cold or Exercise, Yields the Key to Weight Control

Fat people have less than thin people. Older people have less than younger people. Men have less than younger women....

Ulcer-causing Bacteria Linked to Higher Diabetes Risk

People who have been infected with the ulcer-causing bacteria Helicobacter pylori are more than twice as likely to develop diabetes later on as people who do not have signs of the infection....

The Pancreas Also Has Taste Buds

Pancreas can taste fructose, hinting at links to diabetes....

Gene Study Sheds Light on Body Clock's Link to Diabetes

A mutation affecting a sleep-wake hormone may disrupt blood sugar control....

New Information on Link between 'Killer Cells' and Diabetes

Our own killer T-cells in the human body which help protect us from disease may inadvertently destroy cells that produce insulin....

Stem Cell Therapy May Reverse Diabetes

An immune regulator from healthy cord blood stem cells (CB-SCs) can "educate" the T cells of a person with type 1 diabetes, enabling the pancreas to produce insulin....

Intranasal Insulin Boosts Cognitive Function

Pooled data suggest that intranasal insulin may have a positive effect on cognition in both impaired and normal subjects....

Overview of AGEs, Part 2

In this week's set of Homerun Slides, we review AGEs and their relation to...

Editor's Note: "Schiff base" and AGEs

Some of you may remember the term "Schiff base" from your days in the chemistry lab, but do you have any idea what this compound has to do with diabetes? When it comes to advanced glycation end products (AGEs), a Schiff base is what...

Overview of AGEs, Part 1

This week we begin a new Homerun Slides series on advanced glycation end-products (AGEs)...

GLP-1's Function in Preserving B-cells

Associations between acute glucose lowering and improved acute insulin secretory responses suggest improved β-cell function. Comparing and assessing effects of pharmacological therapies used to control hyperglycemia on β-cell...

Test Your Knowledge #599: Which of the following abnormalities relating to the incretin pathway...

Which of the following abnormalities relating to the incretin pathway and renal glucose reabsorption are seen in patients with diabetes?