Beta-Cell Dysfunction May Drive Diabetes in Asians
A new published study has found that beta-cell dysfunction, not merely insulin resistance, may explain the early stages of type 2 diabetes in Asian Indians. One-thousand two-hundred sixty-four individuals without known diabetes in the Diabetes...
Transforming Alpha Cells into New Diabetic Treatment
Reprogramming alpha cells into insulin producing beta cells can be used to treat diabetes….
Sleep Deprivation Suppresses Genes Linked to Metabolism
Healthy people in a laboratory study who slept for no more than six hours a night showed suppression in genes that regulate metabolism as well as the immune system and stress response, which may increase their risk of diabetes, obesity and heart...
Transforming Alpha Cells Into Beta Cells: a Novel, Complementary Approach for Treating Type 2 Diabetes in the Future
A team of American scientists has successfully reprogrammed insulin-producing cells in an effort to discover a new way to fight diabetes. They treated human islet cells with a chemical that inhibits a protein that puts methyl chemical groups...
Possible Type 1 Cure Normalizes Blood Sugars
After a single gene therapy session, the dogs recover their health and no longer show symptoms of the disease for over 4 years....
Mechanism that Links Diabetes and Obesity with Cancer Discovered
Sustained high levels of sugars damage our cells and can….
GLP-1 Agonists May Be Effective for Obese Adolescents
Preliminary evidence from a clinical trial suggests that treatment with GLP-1 receptor agonists was associated with….
Women Have to Do 20% More than Men
Women have to do about 20% more exercise to get the same benefits….
Beta Carotene Found to Protect against Genetic Risk for Type 2 Diabetes
Beta carotene, the nutrient that gives red and orange fruits and vegetables their color, might lower a person's risk for type 2 diabetes if….
Genetic Risk Counseling for Diabetes Fails to Alter Behavior
Why didn't genetic risk testing motivate people to make changes?...
New Discovered Genes that Influence Birth Weight, Metabolism and Disease
Researchers have identified four new genetic regions that influence birth weight, providing further evidence that genes as well as maternal nutrition are important for growth in the womb....
Mechanism Leading to Diabetes Blindness Identified
The rare disorder Wolfram syndrome is caused by mutations in a single gene, but its effects on the body are far reaching. The disease leads to diabetes, hearing and vision loss, nerve cell damage that causes motor difficulties, and early...
Why Some Obese May Not Develop Diabetes
A lone genetic mutation appears to simultaneously enhance insulin sensitivity while increasing the risk of obesity....
Diabetes Misdiagnosed in Asians, Native Hawaiians, and Other Pacific Islanders
Asian Americans have an almost 50% higher risk than other Americans of developing diabetes, especially type 2 diabetes....
New Profile Program Discovers Those Predisposed to Type 2 Diabetes
Team finds medically relevant info using personalized "-omics"....
Why WBCs Attack Beta Cells in Type 1 Diabetes
Many genes that influence type 1 diabetes are also found in pancreatic beta cells suggesting that the insulin-producing cells play a role in why white blood cells attack the beta cells leading to type 1 diabetes, according to new research from...
Diabetes May Start in the Intestines
Scientists have discovered that problems controlling blood sugar may begin in the intestines....
Lipid Genetics Linked to Type 2 Diabetes Risk
Genetic predisposition to low HDL cholesterol or high triglycerides associated with increased risk of diabetes....
Gene Study Sheds Light on Body Clock's Link to Diabetes
A mutation affecting a sleep-wake hormone may disrupt blood sugar control....
Oxyntomodulin: Partner to GLP-1?
Oxyntomodulin is a gut peptide released in response to a meal. It is synthesized within specialized enteroendocrine cells called L cells. Oxyntomodulin is released from the intestinal L cells 5-10 minutes after ingestion of food in amounts...
Genetic Disorder Leads to Diabetes Therapy
Clues to development of the pancreas provided by rare genetic disorder could lead to diabetes therapy....
New Target Shows Promise for Type 2 Diabetes
An investigational compound with a novel mechanism of action appears to improve glycemic control in type 2 diabetes....
NIH Findings Have Potential to Curb Obesity and Type 2 Diabetes
Discovery makes white fat mimic energy-burning brown fat, muscle....
ADA: TAK-875 a Novel Agent in the Treatment of Type 2 Diabetes
Takeda Pharmaceuticals recently completed a Phase 2 study with its novel anti-diabetic agent TAK-875, which could help lead to more individualized patient care and diabetes management....
ADA: Restoring Visual Acuity in Diabetes with VEGF Inhibitor
The vascular endothelial growth factor (VEGF) inhibitor ranibizumab (Lucentis) proves promising in treating diabetic macular edema....
New Mechanism Identified That May Provide Potential Cure for Diabetes
Researchers from UCLA's Larry L. Hillblom Islet Research Center have discovered the underlying mechanism that could convert other cells in the body into insulin-making cells, which could provide a potential cure for...
Study Shows Promise for Developing Protein Therapies for Disease Prevention
A computer analysis by two University of Michigan researchers shows promise for helping develop therapies for some major diseases by rescuing proteins that have stopped performing normally....
Transplanting Beta Cells on Disc Possible New DiabetesTreatment
Doctors from Hackensack University Medical Center will be the first to try a procedure on humans with diabetes in hopes of finding a cure....
Insulin-Releasing Switch Discovered
Johns Hopkins researchers believe they have uncovered the molecular switch for the secretion of insulin, providing for the first time an explanation of this process....
Potential New Diabetes Diagnostic Test
The death of insulin-producing beta cells in the pancreas is a core defect in diabetes. Scientists in Italy and Texas now have discovered a new way that these cells die -- by toxic imbalance of a molecule secreted by other pancreatic...
Old Mitochondria May be Responsible for Neuropathy in the Extremities
The finding may eventually lead to new ways to fight neuropathy, a condition that often accompanies other diseases including HIV/AIDS, diabetes and circulatory disorders....
Predicting the Best Response from Metformin via Genetic Markers
Common variants are associated with glycemic response to metformin in Type 2 diabetes....
Missing Sugar Molecule Raises Diabetes Risk in Humans
Findings help refine understanding of why obese humans appear to be particularly vulnerable to Type 2 diabetes....
Risk of Type 2 Associated with Gene Variations
For individuals of white European descent, certain variations of the gene HMGA1 are associated with Type 2 diabetes....
Research Illuminates Cell Pathway Key to Insulin Resistance in Type 2 Diabetes
A research team, led by La Jolla Institute scientist Joel Linden, Ph.D., has shed new light on the problem of insulin resistance, and identified the key participants in a molecular pathway that holds therapeutic promise for reducing the...
TYK #562: Which of the following abnormalities relating to the incretin pathway and renal glucose reabsorption are seen in patients with diabetes?
New Evolutionary Gene Variants Discovered That Can Explain the Cause for Diabetes
Researchers at the Stanford University School of Medicine have identified genetic variations in a hormone involved in the secretion of insulin that occur more frequently in some human populations than others....
The Pathway from Diabetes to Cancer
Increased insulin, IGF-1, and IGF-2 signaling through the insulin receptor and IGF-1 receptor can induce....
Why Some Diabetes Patients Escape Complications
Much research has been carried out on why diabetes patients develop complications. Now researchers are asking the question the other way around. They want to know why some diabetic patients do not develop complications. What is it that...
MicroRNAs Could Increase the Risk of Amputation in Diabetes Patients
New research has found one of the smallest entities in the human genome, micro-RNA, could increase the risk of limb amputation in diabetic patients....
Why Coffee May Help Protect against Diabetes
Coffee can give you a jump-start to the day but numerous studies have shown that it also may be protective against Type 2 diabetes....
Birch Bark Ingredient Has Metabolic Benefits
In mice, a compound known as betulin lowered cholesterol, helped prevent diet-induced obesity and improved insulin sensitivity....
Researchers Uncover Mechanism for Chronic Inflammation in Type 2 Diabetes
Researchers from Boston University School of Medicine have demonstrated that certain T cells require input from monocytes in order to maintain their pro-inflammatory response in people with Type 2 diabetes....
Off. On. Off. On. The Circuitry of Insulin-Releasing Cells
Researchers at the Johns Hopkins University School of Medicine have teased out how these cells interpret incoming signals and find that three proteins relay signals similar to an electrical circuit....
New Possible Cure in Sight
New Possible Cure in Sight: Professor Ann Simpson and her team at the University of Technology, Sydney, believe their research could lead to a treatment for Type 1 diabetes within 3 years, after they successfully reversed the debilitating disease...
Search for Diabetes "Cure" Focuses on Beta-Cell Regeneration
A simple strategy of just combining two FDA approved drugs (Januvia® + Prevacid®) may restore normoglycemia....
Letter from the Editor #552: Genetic Cause of Diabetes, Perfect Gifts for the Holidays
Last week we published an article, New Analysis Concludes Cause of Diabetes Not Genetic, which focused on the concept that no...
TYK #552: Which one of the following statements about glucagon-like peptide 1 (GLP-1) is not true?
Which one of the following statements about glucagon-like peptide 1 (GLP-1) is not true?
Rebuttal to the Analysis that the Cause of Diabetes is Not Genetic
From Constantin Polychronakos, M.D., F.R.C.P.C., Professor, Departments of Paediatrics and Human Genetics, Director, Division of Endocrinology, McGill University Health Centre, comes a response to last week's article,
New Mechanism Discovered for Controlling Blood Sugar Level
New Mechanism Discovered for Controlling Blood Sugar Level: According to Professor Andrew Tobin (University of Leicester, UK), in order to maintain the correct levels of sugar, a protein, called the M3-muscarinic receptor, present on the cells that...
New Analysis Concludes Cause of Diabetes Not Genetic
Since sequencing the human genome, genetic researchers have searched intensively but unearthed little evidence to suggest that inherited genes cause common diseases....
Secret to Gluconeogenesis in the Liver Discovered
The liver's sweet spot for glucose production is controlled by SRC-1, a steroid receptor coactivator....
Dietary Intervention Can Prevent Disease Process Leading to Type 1 Diabetes
A Finnish study confirms the hypothesis that infant feeding plays a role in the initiation of the disease process leading to Type 1 diabetes in children carrying increased genetic disease risk....
New Protein Found that Causes Inflammatory Response Leading to Insulin Resistance
New Protein Found that Causes Inflammatory Response Leading to Insulin Resistance: It has long been known that overactive immune cells can cause inflammation throughout the body, leading to insulin resistance and eventually Type 2 diabetes. Now, a...
Beta-Cells Stop Replicating after Age 30
A new study has revealed that beta cells-responsible for making insulin in the human body do not replicate after the age of 30….
Editor's Note: Multiple Insulin Regimens and HOMA
As patients progress through the stages of diabetes from the simple use of Metformin to complex basal/bolus insulin regimens there are many stops along the way. This week Dr. Edelman and Dr. Henry focus on multiple shot insulin regimens for Type 2...
Stem Cell Line Offers Fresh Approach to Diabetes Cure
Australian researchers have developed the country's first diabetes specific stem cell line, a major advance for patients suffering from the chronic disease....
What to know about genetic testing and counseling
Testing for monogenic diabetes involves providing a blood sample from which DNA is isolated. The DNA is analyzed for changes in the genes that cause monogenic diabetes. Abnormal results can determine the gene responsible for diabetes in a...
Hope through Research
Researchers are studying the genetic causes of and metabolic processes related to diabetes. Discoveries about monogenic forms of diabetes may contribute to the search for the causes of and treatments for Type 1 and Type 2 diabetes. For...
Scientists Reveal New Clues to Origin of Diabetes
Scientists have identified events inside insulin-producing pancreatic cells that set the stage for a neonatal form of non-autoimmune Type 1 diabetes, and may play a role in Type 2 diabetes as well....
Diabetes Gene Linked to Degeneration of Enzyme Involved in Alzheimer's
Researchers have found that a gene associated with the onset of Type 2 diabetes also is found at lower-than-normal levels in people with Alzheimer's disease....
Identification of a Gene Linked to Both Alzheimer's Disease and Type 2 Diabetes
A research team has identified the mechanism behind a single gene linked to the causes of both Alzheimer's disease and Type 2 diabetes. A gene for a protein called SorCS1, which can cause Type 2 diabetes, impacts the accumulation of...
EASD: Weight Loss with SGLT2 Inhibitors but More Infections
Three possible first in class drugs in the sodium glucose co-transporter (SGLT2 inhibitor) class showed improvements in glycemic control and weight loss, but infections proved troublesome, researchers...
Immune System Genes Contribute to Type 1 Diabetes
Immune System Genes Contribute to Type 1 Diabetes: A new study found a link between immune system genes and the risk of Type 1 diabetes. Using a genome-wide association study, the researchers found that a certain group of genes that react in...
Why Fad Diets Work Well for Some but Not Others
According to published research, genes are interacting with diet, rather than diet alone and are the main causes of variation in metabolic traits, such as body weight....
Protein Important in Diabetes May Also Play a Key Role in Heart Disease, Other Disorders
Studying a protein already known to play an important role in Type 2 diabetes and cancer, genomics researchers have discovered that it may have an even broader role in disease, particularly in other metabolic disorders and heart disease....
Novel Anti-Diabetes Mechanism Uncovered by Scientists
In a joint study, scientists from The Scripps Research Institute and the Dana-Farber Cancer Institute at Harvard University have uncovered a novel mechanism that dramatically increases insulin sensitivity and reduces the risk of developing...
New Enzyme Detects Diabetes and Prediabetes
Having discovered a dramatic increase of an easy-to-detect enzyme in the red blood cells of people with diabetes and prediabetes, Johns Hopkins scientists say the discovery could lead to a simple, routine test for detecting the subtle...
Understanding the Body's Response to Fasting Can Lead to Therapies for Metabolic Disorders
Massachusetts General Hospital (MGH) investigators have found that an enzyme with several important roles in energy metabolism also helps to turn off the body's generation of fats and cholesterol under conditions of...
ADA: First-in-Class Novel Drug Lowers Blood Glucose and Weight
In early trials, a novel sodium glucose co-transporter 2 (SGLT2) inhibitor appears to improve glycemic control and reduce weight among patients on metformin, researchers reported....
Insulin Peptide Points to a Solution for Type 1 Diabetes
Researchers at National Jewish Health and the University of Colorado Anschutz Medical Campus have identified the precise protein fragment, or peptide, that can trigger diabetes in mice....
AFREZZA(TM) Demonstrates Non-Inferiority Compared to Standard Therapy
Findings show reductions in HbA1c levels, plus significantly lower rates of hypoglycemia and fasting blood glucose levels....
Discovery of Important New Player in Diabetes Onset
A research team led by a La Jolla Institute scientist has unmasked a previously unknown cellular player, which is critical to proper insulin secretion....
How Genetic Mutations May Cause Type 1 Diabetes
Scientists have provided an answer to the 40-year-old mystery of how certain genetic mutations lead to Type 1 diabetes. This new molecular understanding could lead to novel therapies for Type 1 diabetes and other autoimmune...
Joslin Identifies Source of Beta Cell Damage
Scientists at the Joslin Diabetes Center, Boston, MA, led by Principal Investigator Robert Stanton, M.D., have discovered that high blood glucose levels damage a key enzyme that guards insulin-producing beta cells. Their surprising finding...
Discovery of a New Receptor Antagonist Predicts Diabetes 2 Onset
Elevated levels of interleukin-1 receptor antagonist (IL-1Ra), a natural inhibitor of interleukin-1 beta, precedes the onset of Type 2 diabetes
Issue 98 Item 1 Exercise in a Pill Fools Body, Has the Effect of Active Exercise
Run a mile sitting in your chair. The AMPK system is activated in cells when they run short of energy, and it triggers the uptake and metabolism of glucose and fats
Issue 91 Item 10 Researchers ID Hormone That Regulates Fat in Cells
Leptin got rid of unwanted fat build-up in muscle tissue and lowered insulin resistance.
Issue 202 Item 4 Diabetes Susceptibility Gene Discovered
The genetic studies have nailed down HNF4a as a diabetes susceptibility gene.
Incretins, Part 5 of 7
In this week's Homerun Slides, Incretins, Part 5 of 6, we review the tissue-specific...
Incretins, Part 2 of 7
This week with Part 2 of our new Incretins series of Homerun Slides, we cover...
Incretins, Part 1 of 7
This first of seven sets of Homerun Slides begins with GLP-1 physiology, then...
Insulin Resistance, Part 3 of 3: Metabolic Markers
Adiponectin is an adipocyte-derived protein that plays an important...
Insulin Resistance, Part 2 of 3: Inflammation Markers
Plasminogen is an acute phase protein and precursor to plasmin, which...
Brian Wansink, PhD, Q3: What Do You Do About Carbs?
Brian Wansink shares his tips on the best ways to get patients to...
Brian Wansink, PhD, Q4: What Challenges Do Different Ethic Groups Face?
Brian Wansink reviews some of the challenges some...
Robert Stanton, MD: The Research on Low-Protein Diets and Kidney Disease
Dr. Stanton gives us his perspective on low-protein diets with a brief...
Dr. Gregory Frost Introduction
Dr. Frost introduces himself to us and talks about Halozyme, and how...
