High Blood Glucose Increases CKD Chances in Elderly
Elderly people with the metabolic syndrome defined as having multiple risk factors associated with developing diabetes and heart disease, had an increased risk of CKD....
Excess Mortality for Adults with Young-Onset Diabetes Persists
Excess mortality rates persist among adults with young-onset diabetes, and are mainly due to ESRD and CAD....
Diabetes Patients Risk for Death Greatly Increases with Kidney Damage
Control of blood sugar and catching early signs of damage may help prevent advanced kidney disease and death....
Kidney Failure Follows Metabolic Pathway
A protein kinase known as ROCK1 can exacerbate an important process called fission in the mitochondria, the power plants of cells, leading to diabetic kidney disease....
Predicting Kidney Disease in Diabetes Using Tumor Necrosis Factors
According to the results of two 12-year studies, levels of circulating tumor necrosis factor receptor 1 and 2 (TNFR1 and TNFR2) predicts kidney disease in both type 1 and type 2 diabetes....
Strict Glycemic Control May Not Help Kidney Patients
Both tight glycemic control and poor glycemic control are associated with worse outcomes in diabetes patients with chronic kidney disease....
In Diabetes with CKD, Moderate Glycemic Control May Be Ideal
In patients with diabetes and CKD, HbA1c targets that fall between 7% and 9% may be associated with decreased risk for adverse outcomes, whereas levels either above or below this range may increase this risk....
Kidney Risk Higher in Diabetic Women than Men
Women with type 2 diabetes are more likely to have risk factors for chronic kidney disease than men, which may also put them at risk for poorer outcomes....
Calcium Score Predicts CVD Risk in Kidney Disease
In patients with CKD, coronary artery calcification predicted the risk of CVD events, especially in those with no history of it....
Poor Glucose Control Ups Mortality in Diabetes Patients on Dialysis
Poor glycemic control, whether too high or too low, is associated with decreased survival in diabetic patients on hemodialysis....
FDA Recommends Vytorin for CVD Prevention in Predialysis CKD Patients
An FDA advisory committee has recommended unanimously that the ezetimibe-simvastatin combination pill (Vytorin) be approved for prevention of cardiovascular disease in CKD patients who are not on dialysis....
FDA Panel Says Vytorin Okay for Some Kidney Disease Patients
An FDA advisory committee has recommended unanimously that the ezetimibe-simvastatin combination pill (Vytorin) be approved for prevention of cardiovascular disease in CKD patients who are not on dialysis....
Earlier Nephrology Interventions Don't Result in Lower Mortality Rates
Patients approaching end-stage renal disease are increasingly receiving the nephrology consultation they need before initiating kidney dialysis; however, the trend has surprisingly not resulted in an improvement in mortality rates,...
Alpha-Lipoic Acid May Improve Diabetic Polyneuropathy
Four years of treatment with alpha-lipoic acid for diabetic polyneuropathy failed to achieve the study's primary endpoint but did yield some clinically meaningful improvements, an international team reports....
Waistline Predictor of Mortality for Kidney Patients
Belly fat is better predictor of mortality than body-mass index alone....
A Caucasian Man with Newly Diagnosed Type 2 Diabetes and Renal Insufficiency, PART 3
Case Presentation, PART 3: Mr. Walker is a 59-year-old Caucasian who presents for evaluation of his type 2 diabetes, discovered 6 months ago by a random glucose measurement of 250 mg/dL using his wife's blood ...
Fatty Liver and Diabetic Kidney Disease: Caused by the Same Mechanisms?
Non-alcoholic fatty liver disease (NAFLD) has been linked to an increased risk of developing cardiovascular disease....
A Caucasian Man with Newly Diagnosed Type 2 Diabetes and Renal Insufficiency, Part 1
Mr. Walker is a 59-year-old Caucasian who presents for evaluation of his type 2 diabetes, discovered 6 months ago by a random glucose measurement of 250 mg/dL using his wife's blood glucose meter....
HbA1C Test Poorly Predictive in Dialysis Patients
Conventional glucose control monitoring methods may not be as meaningful in diabetes patients with end-stage renal disease, researchers found. Patients on dialysis will normally show a lower A1c than they actually have, giving patients and...
Risk Factors for the Development of Albuminuria and Renal Impairment in Type 2 Diabetes
Distinct sets of risk factors were associated with the development of albuminuria and renal impairment consistent with the concept that they are not entirely linked in patients with type 2 diabetes....
ACE-I Lowers the Risk for Renal Disease in Obese Patients
Angiotensin converting enzyme (ACE) inhibition with the drug ramipril reduced the rate of renal events among patients with proteinuria in all body mass index (BMI) strata, but the effect was greater among obese patients....
Kidney Risk Determined Early in Life
Lifestyle decisions made before age 30 appear to determine a person's risk of developing chronic kidney disease many years down the road....
Diet Reverses Kidney Failure in Experimental Model
A controlled diet high in fat and low in carbohydrate can repair kidney damage in diabetic mice....
Antifibrotic May Slow Diabetic Nephropathy
Diabetic nephropathy may not just slow but may actually improve with the novel antifibrotic agent pirfenidone (Esbriet)....
Use of Three Markers for Kidney Disease Can Help Predict Risk of Kidney Failure, Death
Combining the CKD markers of creatinine-based estimated glomerular filtration rate and urine albumin-to-creatinine ratio with the biomarker cystatin C was associated with improved prediction of end-stage kidney disease and all-cause...
New Targets in Preventing End-Stage Renal Disease and Death of Diabetes Patients
Patients with both Type 1 diabetes and CKD have an increased risk of adverse outcomes....
Blood Pressure Drug Delays Kidney Disease in Diabetes Patients
The drug pressure-reducing medication olmesartan, brand name Benicar, could increase the time before any kidney problems were evident by 23 percent. But experts are concerned about higher deaths from heart problems....
Diabetes Patients Not Benefiting from Advances in Kidney Care
Despite significant advances in kidney care over the past 20 years, efforts to improve therapy for Type 1 diabetes patients with kidney dysfunction remain unsuccessful....
Study Calls for Greater Awareness of Connection between Diabetes and Kidney Disease
The first time that many patients realize that diabetes can affect their kidneys is when they are referred to renal services....
Why Some Diabetes Patients Escape Complications
Much research has been carried out on why diabetes patients develop complications. Now researchers are asking the question the other way around. They want to know why some diabetic patients do not develop complications. What is it that...
Even Greater Risk of Nephropathy in Hypertensive Diabetes Reported
The lifetime risk of nephropathy among hypertensive patients with Type 2 diabetes may be greater than previously reported....
Including Proteinuria Can Improve Staging for Chronic Kidney Disease
Using proteinuria in combination with eGFR may reduce unnecessary referrals for care at the cost of not referring or delaying referral for some patients who go on to develop kidney failure, according to Canadian researchers....
More Diabetic Nephropathy in the Winter
Researchers found a seasonal variation in urinary albumin-to-creatine ratios (UACR) in patients with Type 2 diabetes....
Test Your Knowledge #555: A 55-year-old man who has Type 2 diabetes, obesity, hypertension
A 55-year-old man who has Type 2 diabetes, obesity, hypertension, and hypercholesterolemia recently had an abnormal result on a cardiac stress test.
Veggie Diet Best for Kidney Patients
A grain-based vegetarian diet may be better than a meat-based diet in terms of holding down phosphorus levels in patients with CKD....
Diabetes Microvascular Complications, Part 2
The exact mechanism of extracellular matrix accumulation and...
Jumping the Gun on Dialysis Hikes Mortality Risk
Starting dialysis at a higher glomerular filtration rate earlier in the end-stage renal disease process may actually increase mortality, researchers affirmed....
Have Patients Urinate for Their Hearts' Sake
A new multi-marker approach for the prediction of heart failure incidence….
Pomegranate Juice Helps Kidney Patients
Researchers in Israel report that there could be some truth to some of the many health claims for pomegranate juice, at least for kidney patients on dialysis....
Some Alcohol Use Reduces Diabetes, Mortality after Kidney Transplant
Kidney transplant recipients who consume moderate amounts of alcohol have lower mortality rates by 44% and lower levels of diabetes than transplant recipients who are abstainers or heavy drinkers, according to new research....
Kidney Disease Linked to Maternal Diabetes
A new study has found that kids with Chronic Kidney Disease (CKD) are more likely to have mothers who were obese or had diabetes during pregnancy....
Metformin Protects Kidney Function Better than Sulphonylurea
Metformin is more protective of the kidneys than sulphonylurea or sulphonylurea plus metformin among patients with diabetes, researchers said....
Proteinuria Helps Predict Kidney Injury
Proteinuria, in addition to estimated glomerular filtration rate (eGFR), predicts an increased risk of acute kidney injury, investigators reported....
Paricalcitol (Vit. D) Significantly Reduces Albuminuria
The addition of a vitamin-D receptor activator, paricalcitol (Zemplar, Abbott Laboratories), to therapy in patients with diabetic nephropathy reduces albuminuria and risk of kidney failure....
Starting Dialysis Earlier May Be Harmful
Beginning dialysis therapy earlier in the development of advanced kidney disease appears to be associated with a greater risk of death for some patients in the following year, according to a report....
Fetal Exposure to Maternal Type 1 Diabetes Associated with Renal Dysfunction at Adult Age
Reduced functional reserve may reflect a reduced number of nephrons undergoing individual hyperfiltration. If so, offspring of Type 1 diabetic mothers may be predisposed to glomerular and vascular diseases....
Drop Seen in Rate of End-Stage Kidney Disease in Diabetes Patients
However, as diabetes has surged actual number of cases rose, review of U.S. data found....
Chromium Picolinate Reduces Inflammation in Diabetic Nephropathy
Researchers in a new study found that taking chromium picolinate may help lessen inflammation associated with diabetic nephropathy…
New Way to Explain the Leading Cause of Kidney Failure
New reported evidence offers a completely new explanation for why people with diabetes account for more than half of all patients requiring dialysis or kidney transplantation....
Kidney Function in Patients with Diabetic Nephropathy Linked to Seasonal BP
Researchers say clinicians should consider seasonal variations in systolic blood pressure when treating patients with diabetic nephropathy, after finding seasonal variations in urinary albumin-to-creatinine ratio (UACR), likely linked to...
Urine Protein Analysis May Help Spot Diabetic Nephropathy
Certain urine proteomic profiles may be useful biomarkers in the differential diagnosis of diabetic glomerulosclerosis, researchers report in Diabetes Care…
Study Questions Aggressive Glucose Control in All Patients with Diabetes and Renal Failure
Aggressive glucose control does not improve survival in patients with diabetes and renal failure, according to a study. The results suggest that physicians should individualize hemoglobin (Hb) A1c targets for these patients and not rely on...
Patients in Early Stages of Kidney Disease Need Stroke Monitoring
Millions of Americans in the early stages of chronic kidney disease (CKD) are at an increased risk of having atrial fibrillation (AF) -- a major risk factor for stroke -- according to new research…
Test Your Knowledge #533: A Woman with Hypertension, Obesity and Type 2 Diabetes Characterized by Prominent Postprandial Hyperglycemia Objective, Part Two of Three
Mrs. Robinson is a 55-year-old African-American woman who presents for a routine follow-up visit.
Aggressive Blood Sugar Control May Not Improve Survival in ESRD Patients
Aggressive blood sugar control does not improve survival in diabetic patients with kidney failure, according to a study…
Dialysis More Likely than Death in Blacks with ESRD
African Americans with hypertension-associated kidney disease were more likely to develop end-stage renal disease (ESRD) than to die, researchers conducting a long-term cohort study said....
Test Your Knowledge #531: A Caucasian Man with Newly Diagnosed Type 2 Diabetes and Renal Insufficiency, Part Three of Three
Mr. Johnson is a 58-year-old Caucasian who presents for evaluation of his Type 2 diabetes, discovered 6 months ago by a random glucose measurement of 250 mg/dL using his wife's blood glucose meter. Mr. Johnson visited his physician a few ...
First-Void Urine Predicts Renal Events
A morning urine test is superior to all other tests for detecting declining kidney performance in patients with diabetic kidney disease. "From a clinical point of view, these results are very important, because they...
Substantial Differences in the Treatment for End-Stage Kidney Disease in Older Adults
There is substantial regional variation in treatment practices for care of older adults with end-stage renal disease (ESRD), including receipt of hospice care and discontinuation of dialysis before death, according to a...
Test Your Knowledge #530: A Caucasian Man with Newly Diagnosed Type 2 Diabetes and Renal Insufficiency, Part Two of Three
Mr. Johnson is a 58-year-old Caucasian who presents for evaluation of his Type 2 diabetes, discovered 6 months ago by a random glucose measurement of 250 mg/dL using his wife's blood glucose meter. Mr. Johnson visited his physician a few days...
Correlation Between Nonalcoholic Fatty Liver Disease and Microalbuminuria in Prediabetes and Type 2 Diabetes
Correlation Between Nonalcoholic Fatty Liver Disease and Microalbuminuria in Prediabetes and Type 2 Diabetes: The association between nonalcoholic fatty liver disease (NAFLD) and microalbuminuria was evaluated in 1,361 patients with prediabetes or...
Test Your Knowledge #529: A Caucasian Man with Newly Diagnosed Type 2 Diabetes and Renal Insufficiency, Part One of Three
Mr. Johnson is a 58-year-old Caucasian who presents for evaluation of his Type 2 diabetes, discovered 6 months ago by a random glucose measurement of 250 mg/dL using his wife's blood glucose meter. Mr. Johnson visited his physician a few days...
Fact: Twenty Percent Increase in Kidney Failure among People with Diabetes
Twenty Percent Increase in Kidney Failure among People with Diabetes: Between 2003 and 2009 there was a 20% increase in people with diabetes needing dialysis or a kidney transplant, as reported by the UK's National Diabetes Audit. The audit also...
Fact: Vitamin B Therapy Decreases GFR and Increases Vascular Events in Diabetes Patients with Retinopathy
Vitamin B Therapy Decreases GFR and Increases Vascular Events in Diabetes Patients with Retinopathy: The multicenter, double-blind Diabetic Intervention with Vitamins to Improve Nephropathy (DIVINe) study assessed the effects of vitamin B therapy...
Atorvastatin vs. Rosuvastatin in Protecting Kidneys
Results of two related trials investigating the effects of statins on urinary protein excretion and kidney function found atorvastatin (ATV) protective and rosuvastatin (RSV) unprotective, and possibly harmful, in diabetic and nondiabetic...
Heart Beat May Provide Clues to Kidney Health
Individuals with a high resting heart rate and a low beat-to-beat heart rate variability have an increased risk of developing kidney disease, according to a study....
Race and Income Combine to Make Perfect Storm for Kidney Disease
African Americans with incomes below the poverty line have a significantly higher risk of chronic kidney disease (CKD) than higher-income African-Americans or whites of any socioeconomic status....
Albuminuria, eGFR, Predict CV and All-Cause Death
Both estimated glomerular filtration rate (eGFR) and albuminuria independently predict all-cause and cardiovascular mortality, according to the results of a large, global collaborative meta-analysis including more than a million...
Calcium Supplements Can Increase Risk of Kidney Failure
Negative health effects linked to taking too much supplemental calcium are on the rise. Milk-alkali or calcium-alkali syndrome is growing in large part because of widespread use of over-the-counter calcium and vitamin D...
Microalbuminuria Can Predict Renal and Cardiovascular Disease
Microalbuminuria may predict renal and cardiovascular disease in patients with hypertension but without diabetes, according to the results of a study....
Urinary Protein Marks Renal Risk in Hypertension
Elevated urinary albumin may be a trouble sign for the kidneys and heart in hypertensive patients even without diabetes, researchers found....
High Doses of B Vitamins Associated with Increased Decline in Kidney Function for Patients with Kidney Disease from Diabetes
Patients with diabetic nephropathy (kidney disease caused by diabetes) who received high dose B-vitamin therapy experienced a more rapid decline in kidney function and had a higher rate of heart attack and stroke than patients who...
New Earlier Marker of Diabetic Nephropathy than Microalbuinuria
Traditionally, the appearance of microalbuminuria has been used to detect the onset of diabetic nephropathy (DN), and its appearance prompts aggressive treatment. A new marker has now been found that can indicate nephropathy before...
B Vitamins Associated with Increased Decline in Kidney Function
Patients with diabetic nephropathy (kidney disease caused by diabetes) who received high dose B-vitamin therapy experienced a more rapid decline in kidney function and had a higher rate of heart attack and stroke than patients who received...
Weight Loss and Proteinuria
Obesity is a risk factor for the progression of chronic kidney disease (CKD). This study aimed to determine the effect of intentional weight loss on proteinuria and kidney function....
Kidney Disease Hides in People with Undiagnosed Diabetes
Kidney Disease Hides in People with Undiagnosed Diabetes: According to a new study, millions of Americans may have chronic kidney disease (CKD) and not know it. CKD was present in 18% of individuals with prediabetes. That means that, of the 60...
Score Card Predicts Survival after Kidney Transplant
An index developed by Canadian researchers appears to accurately predict which end-stage renal disease patients are most likely to achieve maximum survival benefit with a kidney transplant....
Kidney Disease Hides in People with Undiagnosed Diabetes
Millions of Americans may have chronic kidney disease (CKD) and not know it, according to a new study. CKD was present in 18% of individuals with prediabetes....
Millions in United States Have Undetected Chronic Kidney Disease
As many as 13 million Americans may have undiagnosed diabetes or prediabetes and undetected chronic kidney disease (CKD), according to a new study....
Helping Patients Track their "Kidney Number" Could Save Lives
It's a silent epidemic that affects millions of Americans. Chronic Kidney Disease (CKD) is a life-threatening illness that can often be treated successfully if found early, and can be detected at an early stage using simple, inexpensive...
Accuracy of Monofilament Testing to Diagnose Peripheral Neuropathy
The purpose of the study is to summarize evidence about the diagnostic accuracy of the 5.07/10-g monofilament test in peripheral neuropathy.
Issue 95 Item 7 'Metformin Prescribing Guidelines Often Ignored
Metformin can be pulled from market if prescribers don’t develop a better understanding of the prescribing guidelines.
Issue 92 Item 10 Decline In Renal Function After Dialysis Can Be Halved
End-state renal failure can be reduced by 50%
Issue 92 Item 14 Do You Need - Kidney Tests? Do You Know Your GFR? What are You
There are 3 tests recommended now for those at risk for kidney disease.
Issue 91 Item 7 Renin-Angiotensin-Aldosterone Blockade Remains Underused in Type
Given the additional evidence provided by these three studies, clinicians must be encouraged to make use of these agents
Entries (RSS News)
