Issue 454

Test Your Knowledge Issue 454

A 73-year-old man with diabetes comes to the hospital with a stage 2, deep diabetic foot ulcer overlying the fifth metatarsal. Cellulitis surrounds the ulcer, and edema extends proximally over the distal foot; lymphangitis is...

Recent Advances in GLP-1 Receptor Agonists in the Treatment of Type 2 Diabetes

A couple of months ago we had a review of GLP-1 mimetic therapies and studies form the European Association for the Study of Diabetes (EASD) 44th Annual Meeting convened in Rome, Italy, September 8-11, 2008. Many of you emailed me asking for more...

Link Between Bad Air, Diabetes

Approximately 24 million Americans suffer from diabetes. In addition to the consumption of diets high in fat and sugar, a new study suggests that the air you breathe may also be risky, due to increasing insulin resistance and inflammation.

Sleep Apnea Linked To Insulin Resistance, Independent Of Obesity

In a study that addressed the issue of insulin sensitivity with respect to sleep disordered breathing (SDB), they sought to examine the relationship between SDB and insulin resistance. The results definitively link SDB to pre-diabetic changes in...

Low-Carb Diet Burns More Excess Liver Fat Than Low-Calorie Diet

People on low-carbohydrate diets are more dependent on the oxidation of fat in the liver for energy than those on a low-calorie diet, researchers at UT Southwestern Medical Center have found in a clinical study.

Insulin Diabetes Pill To Begin Testing

A pill that could mean the end of insulin injections for diabetics is about to be tested in human trials. It will be taken twice a day and releases insulin into the body over several hours.

Controlling Blood Pressure In Diabetics Boosts Term Births

Intensive antihypertensive therapy leads to improved pregnancy outcomes in women with type 1 diabetes and microalbuminuria or nephropathy, Danish researchers report.

Promising Data For A New First In Class Diabetes Drug

Trodusquemine (MSI-1436), is a new first in class diabetes drug that is early in its testing phase for treating diabetes by reducing weight which then lowers blood sugars, cholesterol and blood pressure.

Metabolic Syndrome Associated With Increased Incident Stroke Risk

The metabolic syndrome (MetS) is associated with a significantly higher risk of incident ischemic stroke, and there is a clear dose-response relationship between the number of MetS components and stroke risk, researchers report.

Which Form of Bariatric Surgery Is The Most Effective for Obese Diabetic Patients?

The 2 major types of bariatric procedures for obese patients — bypass surgery and restrictive surgery — have different effects on gut hormone secretion, and thus on insulin secretion and sensitivity, and needs to be considered when...

Post-Traumatic Stress Disorder a Risk Factor for Metabolic Syndrome And Diabetes

Post-traumatic stress disorder (PTSD) is associated with an increased risk of metabolic syndrome in veterans, according to a new report.

Metabolic Syndrome Linked to Vascular Dementia

Individuals with the metabolic syndrome, which is known to increase the risk of cardiovascular disease, and diabetes may also have an increased risk of vascular dementia, but not Alzheimer's disease.

Saying No to Favorite Foods Harder for Women

New research on the brain suggests that women unconsciously have a tougher time resisting their favorite foods than men do.

Add A Thiazolidinedione Or Exenatide To Orals?

TZDs and exenatide have modest but beneficial effects on glycemic control and are relatively safe in regard to the adverse events studied. Which one produced the better results?

Atenolol Associated With Mortality Benefit For Heart Failure

Randomized trials have demonstrated the efficacy of selected beta- blockers in systolic heart failure, but the comparative effectiveness of different beta-blockers in practice is poorly understood.

Moderate Weight Loss Most Effective Therapy

Survey finds communication gap between patients and physicians and other barriers are making weight loss difficult. Only 60% of physicians recommend weight loss to their diabetic patients.

Americans Just Don’t Get It! The Risks of Diabetes

More people are afraid of being in a plane crash, hit by lightning or bitten by a snake than developing diabetes, according to a recently announced American Diabetes Association survey. In 2007, 233,619 people died from diabetes and 491 died from...