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Dapagliflozin vs. Saxagliptin: Durability of Glycemic Control

Dec 16, 2019
 
Editor: Steve Freed, R.PH., CDE

Author: Nour Salhab, Pharm.D. Candidate, USF College of Pharmacy

Dapagliflozin, a sodium-glucose cotransporter-2 (SGLT2) inhibitor, has been established to have higher glycemic efficacy, reduction in weight, and reduction in systolic blood pressure than the dipeptidyl peptidase-4 (DPP4) inhibitor saxagliptin. Previous studies have not compared both medications in head-to-head trials in the aspects of the durability of control of HbA1c, fasting plasma glucose, systolic blood pressure, and body weight. This study aimed to assess the durability of HbA1c lowering by reviewing three randomized trials of dapagliflozin vs. saxagliptin in patients with type 2 diabetes over short- and long-term follow-up periods....

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