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Cortisol Levels in Patients with Obesity Predict Hypertension and Diabetes 

May 5, 2020
Editor: Steve Freed, R.PH., CDE

Author: Mia Flowers, PharmD. Candidate of Florida Agricultural & Mechanical University School of Pharmacy

Researchers may have found a new way to detect hypertension and diabetes in people with obesity: an alteration in the hypothalamic-pituitary-adrenal (HPA) axis. 

One of the significant risk factors for several morbidities, including diabetes mellitus, obesity may be a result of an alteration in the hypothalamic-pituitary-adrenal (HPA) axis. This study examined the effects of the HPA axis' negative feedback system after 1-milligram dose dexamethasone on cortisol levels to determine if there is an association with diabetes, hypertension, and cortisol. Previous studies have studied alterations in the HPA axis and investigated the significance of the axis' role in fat tissue distribution leading to insulin resistance and response in the sympathetic nervous system, which induces high blood pressure reading in people with obesity. Researchers have hypothesized that this feedback system indirectly causes high levels of cortisol....


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