Type 2 Diabetes

Richard S. Beaser, MD Medications that Increase Insulin Secretion: SULFONYLUREAS CLASS SUMMARY: Action: Insulin secretagogues. Initial effects are to increase insulin secretory capacity. With establishment of long-term glucose control, this increase may not persist and other extrapancreatic effects, either direct or indirect, may also occur. Required for efficacy: Some remaining …

Among diabetes patients receiving metformin, the addition of insulin compared with a sulfonylurea was associated with an increased risk of nonfatal cardiovascular outcomes and all-cause death…. 

Available studies to date looking at the benefits of using SGLT-2 inhibitors have shown positive results…. The discovery of sodium-glucose co-transporter 2 (SGLT2) inhibitors, with a novel mechanism independent of insulin secretion or sensitization, offered a new therapeutic approach for the management of type 2 diabetes mellitus. The aim of this …

Adolescents with type 2 diabetes are at risk of atherosclerosis and cardiovascular disease early on in life…. 

Richard S. Beaser, MD This week’s excerpt covers the following topics: What drugs block glucose absorption How to titrate this class of drugs Learn the contraindications and precautions for the glucose blocking drugs Discover which other drugs can cause serious side effects when used with drugs that block glucose absorption   …

Eating pistachio nuts and almonds could help protect against developing type 2 diabetes in individuals who are already at high risk…. 

Analysis of DNA data reveals important information in largest diabetes genetic study to date…. 

Richard S. Beaser, MD This week’s excerpt covers the following topics: Drug interactions with potential for clinical significance for metformin Contraindications and precautions for metformin Class contraindications and precautions for TZD’s Which TZD interactions are serious and how it is metabolized  

Dapagliflozin as an add-on therapy to glimepiride, pioglitazone, or sitagliptin significantly reduces postprandial plasma glucose in type 2 diabetes patients…. 

Targeted interventions based on genetic risk may not be the best approach for preventing type 2 diabetes and instead universal strategies to prevent obesity should be prioritized….