Type 2 Diabetes

HNF1A is also the gene responsible for (maturity onset diabetes of the young type 3 (MODY3), a rare monogenic cause of diabetes….

Richard S. Beaser, MD This week’s excerpt covers the following topics: What drugs restore incretin function How to titrate GLP-1 agonists Learn the contraindications and precautions for the DPP-IV inhibitors The typical doses for the different DPP-IV’s….

Dr. Tamara Hannon reviews the current standards of care and recommended medications for treating type 2 diabetes in children and adolescents. She discusses the value of the TODAY study and how we need many more studies like this to improve care for this important and increasing group of type 2 …

Dr. Tamara Hannon talks about the increasing prevalence of type 2 in children and adolescents but reiterates that it is still less common to see type 2 than type 1 diabetes in this age group. She comments that in 2002, when she began her practice, that she saw just a …

Dr. Tamara Hannon talks about how many of her pediatric type 2 diabetes patients are overweight (nearly 100%) and how she determines whether they are type 1 or type 2 (mainly through testing for antibodies). She also discusses how all children are currently at risk for obesity and that around …

Dr. Tamara Hannon talks about the difficult subject of type 2 diabetes complications for adolescents and the challenges they face with the prospect of a longer life with type 2. She also discusses some of the research that has come out that seems to show the disease progressing faster in …

Dr. Tamara Hannon explains how her type 2 patients make the transition to adult-care physicians. Because type 2 is far more common in adults, endocrinologists and physicians who treat adults are actually more used to treating the disease than pediatricians who rarely see type 2 patients. 

Dr. Tamara Hannon addresses Steve’s questions on the future of type 2 diabetes in children, noting that unless we can begin to make changes as a society, the rates will just keep increasing as the obesity rates just keep going up.

Richard S. Beaser, MD Medications that Increase Insulin Secretion: SULFONYLUREAS CLASS SUMMARY: Action: Insulin secretagogues. Initial effects are to increase insulin secretory capacity. With establishment of long-term glucose control, this increase may not persist and other extrapancreatic effects, either direct or indirect, may also occur. Required for efficacy: Some remaining …

Among diabetes patients receiving metformin, the addition of insulin compared with a sulfonylurea was associated with an increased risk of nonfatal cardiovascular outcomes and all-cause death….