Type 2 Diabetes

Participants performed significantly worse on the working memory tasks…. Type 2 diabetes can be associated with cognitive impairment and the risk of Alzheimer’s disease. No studies have yet shown how type 2 diabetes affects working memory task and is related to brain function. The study used participants from the Beijing …

Macrophages, a type of immune cell, were found invading pancreatic tissue during the early stages of the disease… Type 2 diabetes is characterized by the loss of beta cells, reduced insulin production and low-grade systemic inflammation. A new study compared healthy mice to obese mice that developed diabetes. The mice were followed …

Free fatty acids may play an important role in the development of diabetes and cardiovascular diseases… Diabetes increases the risk of cardiovascular disease and stroke. About 50% of people with diabetes die of cardiovascular disease. Hyperglycemia causes an increase in free fatty acids (FFA), which is derived from lipolysis. An …

Add-on of saxagliptin plus dapagliflozin shows greater improvements in glycemic control versus the use of single drug with metformin…. Because of the progressive nature of the disease, patients with type 2 diabetes regularly require various antidiabetic agents to achieve and maintain glycemic control. This study assessed the efficacy and safety …

Stress hormones prompt increase of glucose uptake…. Researchers found that brown adipose tissue (brown fat), which is active in adults, acts as one of the bodily tissues that can be encouraged to take up glucose from the bloodstream to use as a fuel source to create body heat. Increasing the …

Twice-daily regimen found to increase LDL, genital infections compared to benefits of once-daily regimen… An investigational SGLT2 inhibitor remogliflozin etabonate showed significant benefits for glucose control in type 2 diabetics in a randomized study. The study enrolled 241 participants with a mean age of 53, and who had a mean …

In a large population of obese individuals undergoing bariatric surgery, British researchers found that surgery reduced the incidence of diabetes… They designed a matched cohort study of adults (age 20 – 100 years) identified from a UK-wide database of family practices, who were obese (BMI ≥30 kg/m2) and did not …

In the 24-week study, improved HbA1c and cholesterol reduced the need for medications…   Type 2 diabetes patients are often advised to make dietary decisions that are high in carbohydrates and low in fat and protein. Increased carbohydrates lead to high postprandial glucose readings. Due to this, there is interest …

In patients at high risk of cardiovascular disease, the risk of diabetes was over three times higher in those with increased serum calcium levels… Calcium is needed for the release of insulin to respond to higher amounts of blood glucose. It is possible that if serum calcium is not well …

The addition of a DPP-4 inhibitor decreased HbA1C while not requiring an increase in insulin, and subjects remained weight neutral without experiencing an increase in hypoglycemic events… Currently approved dipeptidyl peptidase-4 (DPP-4) inhibitors include alogliptin, linagliptin, saxagliptin, sitagliptin and vildagliptin. DPP-4 inhibitors work by enhancing glucose dependent insulin secretion and …