High alanine aminotransferase, γ-glutamyl transferase may predict risk of type 2 diabetes….
Read More »Early Use of Insulin to Improve Beta Cell Preservation
By David Joffe, BSPharm, CDE; Steve Freed, BSPharm CPT; Brandon Flohr, PharmD, and Vanessa Cepero, PharmD, CVS Pharmacy Type 2 diabetes is a heterogeneous disorder, characterized by glucotoxicity, beta cell dysfunction and decreased insulin sensitivity. Presence of amyloid deposits in the islets and decreased beta cell mass are the pathological hallmark …
Read More »EASD: Outpatient Test Discriminates MODY from Type 1 Diabetes
A measure of the postprandial ratio of urinary C-peptide to creatinine (UCPCR) can distinguish maturity-onset diabetes of the young (MODY) from type 1 diabetes mellitus, allowing some children who would otherwise be treated with insulin to receive oral antidiabetic agents alone….
Read More »Managing Clinical Problems in Diabetes, Case Studies, Part 2
Edited by Trisha Dunning AM, RN, MEd, PhD, CDE, FRCNA and Glenn Ward MBBS, BSc, DPhil (Oxon), FRACP, FRCPath This week, we continue with our special series of case discussions. Mrs. TZ was referred by a podiatrist: Mrs. TZ is a 50-year-old woman with Type 1 (she assures me this …
Read More »Diagnosis and Management of Type 2 Diabetes, 10th Edition, Ch 15, Pt 5
Long-Term Complications and Treatments Steve V. Edelman, MD Robert R. Henry, MD Microvascular Complications (cont’d) Gastroparesis This neuropathy should be suspected in patients with nausea, vomiting, early satiety, abdominal distention, and bloating following a meal, and is secondary to delayed emptying and retention of gastric contents. The delay in gastric emptying …
Read More »Normal Glucose in Kids Can Predict Diabetes Later in Life
Increases in fasting plasma glucose during childhood — even though levels remain in the normal range — can predict adult prediabetes and Type 2 diabetes later in life, a retrospective cohort study showed…..
Read More »What to know about genetic testing and counseling
Testing for monogenic diabetes involves providing a blood sample from which DNA is isolated. The DNA is analyzed for changes in the genes that cause monogenic diabetes. Abnormal results can determine the gene responsible for diabetes in a particular individual or show…
Read More »What is maturity-onset diabetes of the young (MODY)?
MODY is a monogenic form of diabetes that usually first occurs during adolescence or early adulthood. However, MODY sometimes remains undiagnosed until later in life. A number of different gene mutations have been shown to cause MODY, all of which limit the ability of…
Read More »What is neonatal diabetes mellitus (NDM)?
NDM is a monogenic form of diabetes that occurs in the first 6 months of life. It is a rare condition occurring in only one in 100,000 to 500,000 live births. Infants with NDM do not produce enough insulin, leading to an increase in blood glucose. NDM can be mistaken …
Read More »What is Monogenic Diabetes? Many times misdiagnosed!
The most common forms of diabetes, Type 1 and Type 2, are polygenic, meaning the risk of developing these forms of diabetes is related to multiple genes. But some rare forms of diabetes result from mutations in a single gene and are called monogenic….
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