MODY/LADA

High alanine aminotransferase, γ-glutamyl transferase may predict risk of type 2 diabetes….

By David Joffe, BSPharm, CDE; Steve Freed, BSPharm CPT; Brandon Flohr, PharmD, and Vanessa Cepero, PharmD, CVS Pharmacy Type 2 diabetes is a heterogeneous disorder, characterized by glucotoxicity, beta cell dysfunction and decreased insulin sensitivity. Presence of amyloid deposits in the islets and decreased beta cell mass are the pathological hallmark …

A measure of the postprandial ratio of urinary C-peptide to creatinine (UCPCR) can distinguish maturity-onset diabetes of the young (MODY) from type 1 diabetes mellitus, allowing some children who would otherwise be treated with insulin to receive oral antidiabetic agents alone….

Edited by Trisha Dunning AM, RN, MEd, PhD, CDE, FRCNA and Glenn Ward MBBS, BSc, DPhil (Oxon), FRACP, FRCPath This week, we continue with our special series of case discussions. Mrs. TZ was referred by a podiatrist: Mrs. TZ is a 50-year-old woman with Type 1 (she assures me this …

Long-Term Complications and Treatments Steve V. Edelman, MD Robert R. Henry, MD Microvascular Complications (cont’d) Gastroparesis This neuropathy should be suspected in patients with nausea, vomiting, early satiety, abdominal distention, and bloating following a meal, and is secondary to delayed emptying and retention of gastric contents. The delay in gastric emptying …

Increases in fasting plasma glucose during childhood — even though levels remain in the normal range — can predict adult prediabetes and Type 2 diabetes later in life, a retrospective cohort study showed…..

Testing for monogenic diabetes involves providing a blood sample from which DNA is isolated. The DNA is analyzed for changes in the genes that cause monogenic diabetes. Abnormal results can determine the gene responsible for diabetes in a particular individual or show…

MODY is a monogenic form of diabetes that usually first occurs during adolescence or early adulthood. However, MODY sometimes remains undiagnosed until later in life. A number of different gene mutations have been shown to cause MODY, all of which limit the ability of…

NDM is a monogenic form of diabetes that occurs in the first 6 months of life. It is a rare condition occurring in only one in 100,000 to 500,000 live births. Infants with NDM do not produce enough insulin, leading to an increase in blood glucose. NDM can be mistaken …

The most common forms of diabetes, Type 1 and Type 2, are polygenic, meaning the risk of developing these forms of diabetes is related to multiple genes. But some rare forms of diabetes result from mutations in a single gene and are called monogenic….