In this week's Homerun Slides, explaining the beta-centric classification of diabetes mellitus.
Read More »Diagnosing Diabetes Mellitus in Adults Part 1
In this week's Homerun Slides, the failure of the current classification of diabetes and a comparison of the definition of each current diabetes type.
Read More »Practical Diabetes Care, 3rd Ed., Excerpt #6: Type 2 Diabetes: General Introduction
David Levy, MD, FRCP Introduction: Type 2 Diabetes as a Progressive Condition Glycemia in type 2 diabetes progressively deteriorates with time, usually thought to be related to progressive beta-cell failure. This was demonstrated dramatically in the United Kingdom Prospective Diabetes Study (UKPDS 1998), but the glycemic trends have been less marked …
Read More »What is LADA? – Potential Insights from Ongoing Genetic Evaluations
Type 1 and type 2 diabetes (T1D and T2D) both present with hyperglycemia and have similar chronic complications.
Read More »Handbook of Diabetes, 4th Ed., Excerpt #27: Diabetes in Childhood and Adolescence
Rudy Bilous, MD, FRCP Richard Donnelly, MD, PHD, FRCP, FRACP The vast majority of cases of diabetes in children are type 1, caused by autoimmune destruction of beta cells in the pancreatic islets. A steady increase in the incidence of type 1 diabetes has been reported worldwide (average increase 2.5-3% per year …
Read More »Handbook of Diabetes, 4th Ed., Excerpt #15: Diabetic Nephropathy
Rudy Bilous, MD, FRCP Richard Donnelly, MD, PHD, FRCP, FRACP Diabetic nephropathy is a clinical diagnosis based upon the detection of proteinuria in a patient with diabetes in the absence of another obvious cause such as infection. Many of these patients will also be hypertensive, have retinopathy and, in advanced stages, renal …
Read More »Gestational Weight Gain Associated with Infant Birth Weight in Type 1 Diabetes Mothers
Maternal weight gain is key to controlling infant birth weight…. Infants born to mothers with pregestational diabetes are more likely to experience adverse outcomes, especially an increased birth weight. Previous studies have shown the importance of strict maternal glycemic control to prevent fetal hyperinsulinemia and accelerated growth. Excessive gestational …
Read More »Liraglutide (Victoza) Provides Good Control with Less Hypoglycemia for MODY
Besides sulfonylureas, GLP-1RA can also be a treatment option for HNF1A diabetic patients…. Maturity-onset diabetes of the young adults (MODY) is responsible for 1-2% of all cases of diabetes. HNF1A diabetes is caused by loss of B-cell functions. It is usually misclassified as type 1 diabetes due to common hyperglycemic …
Read More »Handbook of Diabetes, 4th Edition, Excerpt #7: Other Types of Diabetes
Rudy Bilous, MD, FRCP Richard Donnelly, MD, PHD, FRCP, FRACP Maturity-onset diabetes of the young Maturity-onset diabetes of the young (MODY) owes its name to a time when diabetes was defined by age of onset. The nomenclature has stuck, however, and MODY defines usually non-insulin dependent diabetes occurring before the age …
Read More »Handbook of Diabetes, 4th Edition, Excerpt #5: Epidemiology and aetiology of type 1 diabetes
Rudy Bilous MD, FRCP Richard Donnelly MD, PHD, FRCP, FRACP The most common cause of type 1 diabetes (over 90% of cases) is T cell-mediated autoimmune destruction of the islet beta cells leading to a failure of insulin production. The exact aetiology is complex and still imperfectly understood. However, it …
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