MODY/LADA

David Levy, MD, FRCP Introduction: Type 2 Diabetes as a Progressive Condition Glycemia in type 2 diabetes progressively deteriorates with time, usually thought to be related to progressive beta-cell failure. This was demonstrated dramatically in the United Kingdom Prospective Diabetes Study (UKPDS 1998), but the glycemic trends have been less marked …

  Type 1 and type 2 diabetes (T1D and T2D) both present with hyperglycemia and have similar chronic complications.

Rudy Bilous, MD, FRCP Richard Donnelly, MD, PHD, FRCP, FRACP The vast majority of cases of diabetes in children are type 1, caused by autoimmune destruction of beta cells in the pancre­atic islets. A steady increase in the incidence of type 1 dia­betes has been reported worldwide (average increase 2.5-3% per year …

Rudy Bilous, MD, FRCP Richard Donnelly, MD, PHD, FRCP, FRACP Diabetic nephropathy is a clinical diagnosis based upon the detection of proteinuria in a patient with diabetes in the absence of another obvious cause such as infection. Many of these patients will also be hypertensive, have retinopathy and, in advanced stages, renal …

  Maternal weight gain is key to controlling infant birth weight…. Infants born to mothers with pregestational diabetes are more likely to experience adverse outcomes, especially an increased birth weight. Previous studies have shown the importance of strict maternal glycemic control to prevent fetal hyperinsulinemia and accelerated growth. Excessive gestational …

Besides sulfonylureas, GLP-1RA can also be a treatment option for HNF1A diabetic patients…. Maturity-onset diabetes of the young adults (MODY) is responsible for 1-2% of all cases of diabetes. HNF1A diabetes is caused by loss of B-cell functions. It is usually misclassified as type 1 diabetes due to common hyperglycemic …

Rudy Bilous, MD, FRCP Richard Donnelly, MD, PHD, FRCP, FRACP   Maturity-onset diabetes of the young Maturity-onset diabetes of the young (MODY) owes its name to a time when diabetes was defined by age of onset. The nomenclature has stuck, however, and MODY defines usually non-insulin dependent diabetes occurring before the age …

  Rudy Bilous MD, FRCP Richard Donnelly MD, PHD, FRCP, FRACP   The most common cause of type 1 diabetes (over 90% of cases) is T cell-mediated autoimmune destruction of the islet beta cells leading to a failure of insulin production. The exact aetiology is complex and still imperfectly understood. However, it …

  In this week’s Homerun Slides, we begin a series which Dr. Stanley Schwartz presented at the 2014 ADA Scientific Sessions, where he outlined some of the problems with the current diabetes classification system. This first section discusses the definition of LADA and shows how diabetes diagnosis characteristics frequently overlap….

Rudy Bilous MD, FRCP Richard Donnelly MD, PHD, FRCP, FRACP   Diabetes mellitus is diagnosed by identifying chronic hyperglycemia. The World Health Organization (WHO) and the American Diabetes Association (ADA) have used a fasting plasma glucose (FPG) of 126mg/dL.(7 mmol/L) or higher to define diabetes (Table 3.1 ). This originated from epidemiological …