Test Your Knowledge Issue 350

1. Pramlintide, administered subcutaneously, has been shown to have a bioavailability of approximately 38-40%.

2. The time to achieve maximum concentration is 20 minutes, with the effect lasting up to 6 hours after drug administration.

3. Approximately 40% of the administered dose is found unbound in the plasma.

4. Pramlintide does not accumulate with administration of repeated doses.

5. Its elimination half-life is approximately 20-45 minutes.

6. Deslys pramlintide is the primary, active metabolite of the drug.

7. Unlike insulin, which is metabolized approximately 50% in the liver, pramlintide is metabolized and eliminated predominantly by the kidneys.

8. Since pramlintide possesses a wide therapeutic index, dosage adjustments are not required regardless of meal size or in the presence of mild-to-moderate renal insufficiency.

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