This article originally posted 23 January, 2007 and appeared in Issue 348
Higher Glucose Levels Within Normal Range Predicts Diabetes
Higher FPG concentrations within the normal range were an independent risk factor for type 2 diabetes.
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A group of researchers led by Dr Diane Becker of the Johns Hopkins Medical
Institutions in Baltimore, USA, evaluated the risk of developing diabetes in
members of high-risk families with fasting plasma glucose (FPG) concentrations
within the normal range. A total of 542 non-diabetic adults aged 30-59 with
siblings with documented premature coronary disease were followed prospectively
to determine the incidence of type 2 diabetes. The mean follow-up was 8.7 years.
The researchers found that 45 patients (7.8%) developed type 2 diabetes during
the follow-up period. The incidence of diabetes increased with increasing thresholds
of FPG 90-120mg/dL (5.0, - 6.7mmol/L). All FPG thresholds within the normal
range 90-100mg/dL.(5.0 and 5.6mmol/L) had diagnostic efficiency levels >0.74,
and maximal diagnostic efficiency for FPG was achieved at 99mg/dL.(5.50mmol/L).
The researchers concluded that higher FPG concentrations within the normal
range were an independent risk factor for type 2 diabetes in high-risk adults,
and may help identify candidates for primary preventive interventions.
Diabetes Research and Clinical Practice 2006;74:267-73
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