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This article originally posted 23 January, 2007 and appeared in  Issue 348

Higher Glucose Levels Within Normal Range Predicts Diabetes

Higher FPG concentrations within the normal range were an independent risk factor for type 2 diabetes.
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A group of researchers led by Dr Diane Becker of the Johns Hopkins Medical Institutions in Baltimore, USA, evaluated the risk of developing diabetes in members of high-risk families with fasting plasma glucose (FPG) concentrations within the normal range. A total of 542 non-diabetic adults aged 30-59 with siblings with documented premature coronary disease were followed prospectively to determine the incidence of type 2 diabetes. The mean follow-up was 8.7 years.

The researchers found that 45 patients (7.8%) developed type 2 diabetes during the follow-up period. The incidence of diabetes increased with increasing thresholds of FPG 90-120mg/dL (5.0, - 6.7mmol/L). All FPG thresholds within the normal range 90-100mg/dL.(5.0 and 5.6mmol/L) had diagnostic efficiency levels >0.74, and maximal diagnostic efficiency for FPG was achieved at 99mg/dL.(5.50mmol/L).

The researchers concluded that higher FPG concentrations within the normal range were an independent risk factor for type 2 diabetes in high-risk adults, and may help identify candidates for primary preventive interventions.

Diabetes Research and Clinical Practice 2006;74:267-73

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This article originally posted 23 January, 2007 and appeared in  Issue 348

Past five issues: Diabetes Clinical Mastery Series Issue 85 | Issue 626 | Special Edition - Getting Patients on Track | Diabetes Clinical Mastery Series Issue 84 | Issue 625 |

 
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