Duration And Severity Of Obesity Limits Cardiovascular Benefits Of Weight Reduct

During the 20 year follow up there were 1989 major CVD events and 449 incident cases of diabetes in the 7176 men.

Risk of major CVD and diabetes increased significantly with increasing overweight and obesity. During the 15 year follow up, weight gain was associated with increased risk of CVD and diabetes.

Weight loss was associated with lower risk of diabetes than the stable group irrespective of initial weight. No significant cardiovascular benefit was seen for weight loss in any men, except possibly in considerably overweight (BMI 27.5–29.9 kg/m2) younger middle aged men (RR = 0.42; 95% CI 0.22 to 0.81).

Long term risk of CVD and diabetes increased significantly with increasing overweight and obesity. Weight loss was associated with significant reduction in risk of diabetes but not CVD, except possibly in considerably overweight younger men.

Duration and severity of obesity seem to limit the cardiovascular benefits of weight reduction in older men.

Journal of Epidemiology and Community Health 2005;59:134-139

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