Thursday , November 23 2017
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Complications with Bone in Type 2 Diabetes

Trabecular bone score worsens in type 2 diabetes patients….

People with diabetes are prone to having fractures even though their bone mineral density score is within normal ranges. During the American Society for Bone and Mineral Research 2013 Annual Meeting, Dr. Mishaela R. Rubin showed that trabecular bone is affected in patients with type 2 diabetes. The researchers found that the trabecular bone score was worse in patients with diabetes compared to patients without diabetes although the diabetes patients’ density score was within range. This suggests that diabetes can contribute to the defect in the bone and contribute to fracture risk.

The study involved 14 postmenopausal women with type 2 diabetes and 21 controlled patients. The trabecular bone score (TBS) data was found using a DXA image. When comparing these two groups, TBS was found to be lower in patients with type 2 diabetes (1.146 g/cm2 vs. 1.27 g/cm2). Researchers also found that 25-hydroxyvitamin D and P1NP levels were lower in patients with type 2 diabetes than the control group. However, there was a higher bone alkaline phosphatase level in patients with type 2 diabetes.

Practice Pearls:
  • Type 2 diabetes patients had low 25-hydroxyvitamin D levels.
  • Patients with type 2 diabetes had higher bone alkaline phosphatase.
  • Diabetes contribute to bone fracture risk.

American Society for Bone and Mineral Research 2013