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Cardiac Death Risk in Diabetic Hemodialysis Patients Increased Due to Thyroid Problems

A prospective study found that diabetic hemodialysis patients’ subclinical hyperthyroidism and euthyroid sick syndrome might increase the risk of sudden cardiac related deaths…. 

Christiane Drechsler, MD, PhD, of University Hospital Würzburg in Würzburg, Germany, and colleagues conducted a study that included 1,000 patients with diabetic hemodialysis. Of those 1,000 patients, 78.1% had euthyroidism, 13.7% had subclinical hyperthyroidism, 1.6% had subclinical hypothyroidism, and 5.4% had euthyroid sick syndrome. Patients with euthyroidism were compared with those who had subclinical hyperthyroidism and euthyroid sick syndrome in regards to which group showed an increased short-term (within a 12 month period) risk of sudden cardiac death. It showed the patients who had euthyroidism had a 2.0 times increased short-term risk of sudden cardiac risk, and those who had subclinical hyperthyroidism and euthyroid sick syndrome had a 2.7 times increase.

The results showed that euthyroid sick syndrome was associated with a three-fold increased risk of short-term mortality, but in the long-term (2-4 years) it showed no increased risk. The study revealed that subclinical hypothyroidism was not associated with cardiovascular events or all-cause mortality, which revealed thyroid disorders, had no influence on the risks of myocardial infarction and stroke. This study led researchers to conclude," Regularly assessing a patient’s thyroid status may help estimate the cardiac risk of dialysis patients."

Practice Pearls: 
  • Patients who had euthyroidism had a 2.0 times increased short-term risk of sudden cardiac risk, and those who had subclinical hyperthyroidism and euthyroid sick syndrome had a 2.7 times increase
  • The results expressed that euthyroid sick syndrome was associated with a three-fold increased risk of short-term mortality, but in the long-term (2-4 years) it showed no increased risk
  • The study revealed that subclinical hypothyroidism was not associated with cardiovascular events or all-cause mortality, which showed thyroid disorders, had no influence on the risks of myocardial infarction and stroke
  • This study led researchers to conclude," Regularly assessing a patient’s thyroid status may help estimate the cardiac risk of dialysis patients."

http://www.renalandurologynews.com/thyroid-problems-up-cardiac-death-risk-in-diabetic-hd-patients/article/348571/