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Canagliflozin for Those on Triple Drug Therapy with Uncontrolled Diabetes 

Feb 29, 2020
 
Editor: David L. Joffe, BSPharm, CDE, FACA

Author: Antonio Bess, Pharm D Candidate, Florida Agricultural & Mechanical University School of Pharmacy

SGLT-2 inhibitors have proved to be successful hypoglycemics, so should they be recommended earlier for those not achieving goal A1c reductions? 

Studies have proved sodium-glucose cotransporter 2 (SGLT-2) inhibitors to be useful glucose and A1c lowering therapy in a broad range of patients with type 2 diabetes. Recent studies have assessed their effects on type 1 diabetes, and other studies have concluded that SGLT-2 inhibitors reduce cardiovascular events in people with type 2 diabetes. SGLT-2 inhibitors have been recommended as second-line therapies for those whose safety profiles correlate to the medication. Insulin is used when HbA1c levels are extremely high or when are person is in a state of severe hyperglycemia. Many people are titrated up to insulin once oral therapies have failed. In many instances, patients are reluctant to begin insulin therapy because of its route of administration, a side effect of weight gain, and risk of hypoglycemia. In this analysis, changes in HbA1c and weight are being evaluated for patients who were unwilling to take insulin and received canagliflozin after inadequate responses to maximum doses of 3 oral hypoglycemic agents....

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