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Can Zero Calorie Sweeteners Affect Appetite?

Artificial sweeteners sucralose, acesulfame potassium, and the two combined seem to generate the same neutral reaction on the appetite-reducing hormone GLP-1 as water. After an overnight fast, each subject consumed either 240 ml of water alone or equivalently sweetened with 1) 52 mg sucralose, 2) 200 mg AceK or 3) 46 mg sucralose plus 26 mg AceK. Ten minutes later, each drank 75 g of glucose, made up to 300 ml with water, and containing 150 mg C-acetate. Blood glucose, plasma insulin, total GLP-1, and gastric emptying were evaluated over 240 minutes and researchers found there was no difference between zero calorie sweetened beverages and water. Diabetes Care Dec. 2013