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Production Assistant, Diabetes In Control

Life Happens to Our Patients Too. Be Understanding.

Woman, type 1 diabetes, 63 years of age. Well-educated diabetes wise. Reached out to me saying: "HELP!! Normally I take 10 units of Toujeo at 9 pm. I did that last night. This morning I meant to take an additional 2 units because I'm not getting any exercise due to a knee injury. By mistake I took my usual dose of 10 units." Before I read the rest of her email, I thought, I know her. She knows what to do. She wears a CGM, she’ll be watching that. Then I read on...

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International Textbook of Diabetes Mellitus, 4th Ed., Excerpt #60: Mechanisms of Insulin Signal Transduction Part 4 of 8

PI-3 kinase pathways: regulation of metabolism and gene expression: Signal transduction for insulin’s metabolic effects also diverges from insulin receptor substrate proteins and proceeds via the PI-3 kinase pathway. The first committed step involves type 1A PI-3 kinase, a heterodimer consisting of a p85 regulatory subunit and a p110 catalytic subunit. In quiescent cells, the regulatory subunit maintains a state of low activity for the catalytic subunit.

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Question #870

Test Your Knowledge

According to available evidence, which of the following is a treatment strategy for the delay or prevention of macrovascular complications? 1) Antiplatelet therapy 2) Blood pressure management 3) Glycemic control ≤ 7% (individualized for patients) 4) Smoking cessation 5) Lipid management 6) All of the above Follow the link to see the correct answer!

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