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Production Assistant, Diabetes In Control

Hypoglycemia Treatment

What do you recommend to your patients as the first choice to treat hypoglycemia? 1. Glucose tablets 2. Glucose gel or liquid 3. Juice, soda or milk 4. Honey or cake gel 5. Hard Candy (Smarties) 6. Other Follow the link to share your opinion and see what your colleagues think!

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Question 859

Test Your Knowledge

This class of drugs is typically reserved for individuals with type 1 diabetes or others receiving intensive insulin therapy. It inhibits glucagon secretion and slows gastric emptying: 1. Amylin mimetics 2. GLP-1 receptor agonists 3. DPP-4 inhibitors 4. SGLT-2 inhibitors Did you get it right? Follow the link to find out!

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When Losing Weight, Warn ’em!

I work in obesity medicine. As many of us know, losing weight isn't the problem for most, but weight regain is. As the saying goes for many, you can't be rich enough or thin enough. Many of our patients come in with unrealistic goals regarding their weight loss, and don't give themselves enough credit for the weight they have lost. Many, for many reasons, regain.

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International Textbook of Diabetes Mellitus, 4th Ed., Excerpt #49: Biosynthesis, secretion, and action of glucagon Part 3 of 4

Control of glucagon release: There is considerable evidence that the control of glucagon secretion is multifactorial and involves direct effects of nutrients on alpha-cell stimulus-secretion coupling as well as paracrine regulation by insulin, somatostatin and, possibly, other mediators such as zinc, γ-amino-butyric acid (GABA) or glutamate. Glucagon secretion is also regulated by circulating hormones and the autonomic nervous system.

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Exercise Guidelines

Do you follow the ADA Guidelines and exercise at least 150 minutes a week or 75 minutes of vigorous activity per week? Follow the link to see how you and your colleagues compare!

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Question 858

Test Your Knowledge

This drug class is infrequently used in the U.S. and Europe. Studies suggest this class may modulate FXR- and TGR5-mediated pathways involved in glucose homeostasis. This drug class has the disadvantage that it may decrease the absorption of other medications. 1. DPP-4 inhibitors 2. Bile Acid sequestrants 3. Dopamine-2 Agonists 4. Alpha-glucosidase inhibitors Did you get the right answer? Follow the link to find out!

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Sometimes You Gotta Use the Brand Name

Many of our patients have intolerable GI side effects from metformin. We use ER to try to decrease these, but that doesn’t always work. If they have these symptoms, I recommend they take it slow and take it after they eat. If they still have problems, I recommend they break the tablet to 250mg, even though the label may say one shouldn’t break the tablet.

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International Textbook of Diabetes Mellitus, 4th Ed., Excerpt #48: Biosynthesis, secretion, and action of glucagon Part 2 of 4

Physiologic effects of glucagon: Glucagon acts through binding to specific receptors located at the target cell plasma membrane. The major common effect of glucagon is to activate adenylate cyclase and to increase the intracellular production of cAMP. There is considerable evidence that binding of glucagon to its receptor activates an intermediate transduction process that involves the participation of guanosine triphosphate (GTP), divalent cations, and adenosine (or other similar natural substances).

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