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Production Assistant, Diabetes In Control

International Textbook of Diabetes Mellitus, 4th Ed., Excerpt #30: Insulin Gene Expression and Biosynthesis Part 6 of 6

Regulation of proinsulin conversion: PC2 and PC1/3 are Ca2+-dependent enzyme activities with an acidic pH 5 – 5.5 optimum. Fortunately, the beta granule contains an intraorganellar environment of 1 – 10 mM free Ca2+ and acidic pH 5.5, which ideally suits the requirements for optimal PC2, PC1/3 and CP-H activities within this organelle.

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DIC Updates

Do you look to Diabetes in Control to keep you updated with new treatments? Follow the link to share your opinion.

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Question #839

Test Your Knowledge

During the United Kingdom Prospective Diabetes Study (UKPDS), patients with type 2 diabetes were assigned to the intensive treatment arm (received a sulfonylurea or insulin, or metformin if overweight) or a conventional treatment arm (dietary interventions only). In the intensive treatment arm, which one of the following benefits became apparent only when a 10-year follow-up study was conducted? A. Reduced risk of microvascular complications B. Clinically lower overall BMI C. Reduced risk of myocardial infarction D. Lower overall mean A1C Did you get it right? Follow the link to find out!

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International Textbook of Diabetes Mellitus, 4th Ed., Excerpt #29: Insulin Gene Expression and Biosynthesis Part 5 of 6

Transport of proinsulin from the ER to Golgi apparatus: After proinsulin is translocated into the lumen of the ER, it is then delivered in transport “COP-coated vesicles” to the cis-Golgi apparatus. Up until relatively recently, it was thought that newly synthesized proinsulin was passed from the cis-Golgi network “stack” via the medial- to the trans-stack of the Golgi apparatus stacks in “COP”-coated vesicles,

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ADA News Briefings

Would you be interested in seeing the news briefings from the ADA meeting? Topics include beta-cell replacement, closed loop systems, CVD and diabetes, etc., and feature all the top doctors on each. They last about 45 minutes. Follow the link to cast your vote!

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International Textbook of Diabetes Mellitus, 4th Ed., Excerpt #28: Insulin Gene Expression and Biosynthesis Part 4 of 6

Insulin biosynthesis: the previous section outlines that insulin gene transcription is a highly controlled process. The product of this process, pre-proinsulin mRNA, is unusually stable in pancreatic beta cells and it is further stabilized as glucose concentrations increase. As such, there is normally an abundant source of preproinsulin mRNA in the beta-cell cytosol available for translation.

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Question #837

Test Your Knowledge

The list below indicates the ethnicities of the patients whose cases you have just reviewed over the past month. Please choose the correct order showing the relative risk of developing diabetes for each ethnicity in adults 20 years and older. Select one answer: [A] Non-Hispanic blacks, Hispanic, non-Hispanic whites, Asian American [B] Hispanic, Non-Hispanic blacks, non-Hispanic whites, Asian American [C] Non-Hispanic blacks, Hispanic, Asian American, non-Hispanic whites [D] Hispanic , Non-Hispanic blacks, Asian American, non-Hispanic whites Are you right? Follow the link to respond!

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