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Production Assistant, Diabetes In Control

Question 872

Test Your Knowledge

The United Kingdom Prospective Diabetes Study early results data suggested metformin conferred greater cardiovascular benefits to the overweight diabetes participants than dietary interventions alone. All of the following were observed for the metformin group EXCEPT: A. A relative risk reduction for myocardial infarction of 39%. B. A relative risk reduction for all-cause mortality of 36%. C. A relative risk reduction for diabetes related death of 42%. D. An overall mean A1c reduction of 1.5%. Did you get it right? Follow the link to find out!

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International Textbook of Diabetes Mellitus, 4th Ed., Excerpt #61: Mechanisms of Insulin Signal Transduction Part 5 of 8

PI-3 kinase-independent pathways for stimulation of glucose transport: The CAP/Cbl/TC10 pathway. Substantial evidence confirms the presence of PI-3 kinase independent pathways for stimulation of glucose transport. It had long been clear that other growth factor receptors (i.e., the platelet-derived growth factor (PDGF) receptor, cytokine receptors such as IL-4, and certain integrins) activate PI-3 kinase to the same extent as the insulin receptor with generation of PI(3,4,5)P3, yet still do not stimulate glucose transport.

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Metformin Addition

For a newly diagnosed type 2 patient with an elevated A1c of 7-8%, would you consider an SGLT-2 drug as a second treatment option added to metformin if they are not at goal on metformin? Follow the link to share your opinion and see what your colleagues think!

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