Thursday , February 22 2018
Home / Production Assistant, Diabetes In Control (page 61)

Production Assistant, Diabetes In Control

International Textbook of Diabetes Mellitus, 4th Ed., Excerpt #49: Biosynthesis, secretion, and action of glucagon Part 3 of 4

Control of glucagon release: There is considerable evidence that the control of glucagon secretion is multifactorial and involves direct effects of nutrients on alpha-cell stimulus-secretion coupling as well as paracrine regulation by insulin, somatostatin and, possibly, other mediators such as zinc, γ-amino-butyric acid (GABA) or glutamate. Glucagon secretion is also regulated by circulating hormones and the autonomic nervous system.

Read More »

Exercise Guidelines

Do you follow the ADA Guidelines and exercise at least 150 minutes a week or 75 minutes of vigorous activity per week? Follow the link to see how you and your colleagues compare!

Read More »

Question 858

Test Your Knowledge

This drug class is infrequently used in the U.S. and Europe. Studies suggest this class may modulate FXR- and TGR5-mediated pathways involved in glucose homeostasis. This drug class has the disadvantage that it may decrease the absorption of other medications. 1. DPP-4 inhibitors 2. Bile Acid sequestrants 3. Dopamine-2 Agonists 4. Alpha-glucosidase inhibitors Did you get the right answer? Follow the link to find out!

Read More »

Sometimes You Gotta Use the Brand Name

Many of our patients have intolerable GI side effects from metformin. We use ER to try to decrease these, but that doesn’t always work. If they have these symptoms, I recommend they take it slow and take it after they eat. If they still have problems, I recommend they break the tablet to 250mg, even though the label may say one shouldn’t break the tablet.

Read More »

International Textbook of Diabetes Mellitus, 4th Ed., Excerpt #48: Biosynthesis, secretion, and action of glucagon Part 2 of 4

Physiologic effects of glucagon: Glucagon acts through binding to specific receptors located at the target cell plasma membrane. The major common effect of glucagon is to activate adenylate cyclase and to increase the intracellular production of cAMP. There is considerable evidence that binding of glucagon to its receptor activates an intermediate transduction process that involves the participation of guanosine triphosphate (GTP), divalent cations, and adenosine (or other similar natural substances).

Read More »