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Production Assistant, Diabetes In Control

International Textbook of Diabetes Mellitus, 4th Ed., Excerpt #58: Mechanisms of insulin signal transduction Part 2 of 8

Insulin receptors, ligand binding: The insulin action sequence is initiated with specific binding to high-affinity receptors on the plasma membrane of target cells. The insulin receptor is a large transmembrane glycoprotein consisting of two alpha- and two beta- subunits that form a heterotetramer, as depicted in Figure 12.1. The insulin receptor is synthesized from a single gene as a polypeptide pro receptor comprised of alpha- and beta- subunit sequences in tandem.

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SGLT-2 or No?

Now that we have a drug (SGLT-2) that can prevent the death of those with diabetes by 38%, do you see yourself informing your patients about this option or will you stay with the status quo? 1) inform patients 2) Stay the course Follow the link to share your opinion!

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Question 868

Test Your Knowledge

According to the Standards of Medical Care in Diabetes, which medication class places asymptomatic patients at increased risk of developing type 2 diabetes and is an additional indication for diabetes screening? A. Atypical antipsychotics B. Glucocorticoids C. Both A and B D. Neither A nor B Did you get it right? Follow the link to find out!

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A New Paradigm in the Understanding and Treatment of the Metabolic Syndrome, Part 2

As concluded in the previous newsletter in this series, “Evolutionary selection for insulin resistance in a cyclic environment: brain clocks and control of peripheral metabolism” the brain is equipped with circadian neurophysiological mechanisms to induce (and reverse) the insulin resistant state that evolved as a survival strategy against ensuing environmental stresses such as prolonged (seasonal) lack of food availability. A central facilitator of this insulin resistance induction is a diminution of the circadian peak in dopaminergic activity at the SCN. Neurotoxin induced destruction of these dopaminergic projections to the clock of insulin sensitive animals induces marked insulin resistance and glucose intolerance without alterations in food consumption.

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