Friday , July 20 2018
Home / Production Assistant, Diabetes In Control (page 51)

Production Assistant, Diabetes In Control

International Textbook of Diabetes Mellitus, 4th Ed., Excerpt #80: Insulin Actions In Vivo: Glucose Metabolism Part 6 of 9

Intravenous glucose: In the presence of euglycemia, insulin displays a potent suppressive action on hepatic glucose production, such that portal insulin concentrations of less than 100 mU L−1 abolish glucose entry into the circulation. Figure 14.7 shows a typical time course for endogenous glucose production following an acute increase in plasma insulin to levels of 60 – 70 mU L−1 in a healthy subject.

Read More »

GLP-1 and Basal Insulin

Test Your Knowledge

Which of the following GLP-1 agonists is not currently approved for use with basal insulin? A. Exenatide (Byetta) B. Dulaglutide (Trulicity) C. Albiglutide (Tanzeum) D. Liraglutide (Victoza) E. None of the above Did you get it right? Follow the link to find out!

Read More »

What is the Most Ineffective Medication?

As we know, the most ineffective medication is the one needed but never taken. There are many reasons our patients don’t take prescription medicines, but a biggy is the cost. If a medicine is too expensive, the patient will not fill the prescription, therefore won’t take it. For example, when ordering an SGLT-2 and/or GLP-1, each can cost hundreds or more for a month’s prescription. Some are covered for both. Some are covered for one brand, but not the other.

Read More »

International Textbook of Diabetes Mellitus, 4th Ed., Excerpt #79: Insulin Actions In Vivo: Glucose Metabolism Part 5 of 9

The fed state is the absorptive period between meals. Carbohydrates are normally mixed with lipids and protein in the diet and make up 40 – 60% of the caloric content. Absorption of dietary carbohydrates is influenced by their chemical form (refined sugars or complex carbohydrates) and by other components of food. Furthermore, disposition of dietary carbohydrate is indirectly affected by fats and protein to the extent that these latter (i) compete with glucose as substrates, and (ii) interfere with glucoregulatory hormones by altering insulin secretion.

Read More »