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Production Assistant, Diabetes In Control

International Textbook of Diabetes Mellitus, 4th Ed., Excerpt #47: Biosynthesis, secretion, and action of glucagon Part 1 of 4

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Glucagon, discovered in 1923 as a contaminant of early insulin preparations, has long been a neglected hormone. Glucagon was among the very first polypeptide hormones to be isolated, purified, sequenced, and synthesized. Thanks to the pioneering work of Unger, it was the first polypeptide hormone to become measurable by radioimmunoassay, almost one year before insulin. It has served two Nobel Prize winners as a unique tool, which permitted Sutherland and his associates to discover cyclic AMP (cAMP), and Rodbell and his coworkers to discover the role of G-proteins in cell-membrane receptors.

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Question 856

Test Your Knowledge

This oral drug class focuses on the incretin system and its use leads to increased postprandial GLP-1 and G1P levels: 1. Bile Acid sequestrants 2. DPP-4 inhibitors 3. Dopamine-2 agonists 4. Alpha-glucosidase inhibitors Did you get it right? Follow the link to find out!

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High Cost of Insulin

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What do you feel is the primary reason for the high cost of insulin? 1) Greed 2) Research and Development 3) Corporate Salaries 4) Stockholders Needing a Return on Investment 5) Other Follow the link to share your opinion -- and see what others think!

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Reteach to Dispel Fear and Misunderstandings

Senior Woman Suffering From Headache At Home

Female, 76 years of age, type 2 diabetes, well managed, A1C 6%, on metformin 500mg daily. Patient also has well-managed hypertension, hyperlipidemia, and osteoporosis. She lives alone. Wants tighter diabetes control. Was having hypoglycemia when on 500mg twice daily. Requests, almost begs me, to increase her medication. States she’s afraid she’s going to have kidney problems.

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International Textbook of Diabetes Mellitus, 4th Ed., Excerpt #46: Neuropeptides and Islet Hormone Secretion Part 5 of 5

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Summary of present-day knowledge: We know today that the pancreatic islets are innervated by parasympathetic, sympathetic, and sensory nerves. The parasympathetic nerves stimulate insulin and glucagon secretion whereas sympathetic nerves inhibit insulin secretion and stimulate glucagon secretion; the net influence of the sensory nerves is not yet clearly established.

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