Wednesday , December 13 2017
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Production Assistant, Diabetes In Control

Recommending GLP-1

To your type 1 patients who use large amounts of insulin or are overweight, have you recommended the use of a GLP-1 receptor agonist in their treatment? (See Article #3) 1) Yes 2) No 3) No, but will now consider What do your colleagues think? Follow the link to find out!

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International Textbook of Diabetes Mellitus, 4th Ed., Excerpt #75: Regulation of Glucose Metabolism in Liver Part 11 of 11

Pyruvate dehydrogenase and lipogenesis: The generation of pyruvate via glycolysis and L-PK brings the chapter full circle. Tracer experiments in humans estimate PDH flux to be very small in the postabsorptive liver. However, in the fed state activation of hepatic lipogenesis requires activation of PDH flux to generate acetyl-CoA from carbohydrate. PDH consists of three subunits (E1 – E3) that catalyze the sequential decarboxylation, acetyl-CoA formation and reduction of NAD+ to NADH, respectively.

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