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Production Assistant, Diabetes In Control

International Textbook of Diabetes Mellitus, 4th Ed., Excerpt #144: The Genetics of Type 2 Diabetes Part 6

Gene–gene and gene–environment interactions: Gene–gene interactions, or epistasis, have been suggested as a possible explanation for difficulties in replicating genetic association in complex diseases. The standard statistical methods used in association studies are usually limited to analysis of single marker effects and thereby do not account for interactions between markers. Previous attempts to study epistasis in complex diseases have focused on interactions between candidate regions. However, the recent abundance of GWAS data has made a comprehensive search across the genome more feasible.

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