Sunday , October 22 2017
Home / Production Assistant, Diabetes In Control (page 11)

Production Assistant, Diabetes In Control

International Textbook of Diabetes Mellitus, 4th Ed., Excerpt #85: Measuring Insulin Action In Vivo

DeFronzoCover

Insulin action dynamics: Insulin sensitivity from the clamp is expressed in terms of the steady-state value reached after a period of hyperinsulinemia. A dose–response can be constructed and sensitivity can be expressed as the ED50, that is, the concentration for half-maximal stimulation of Rd as a function of dose. Alternatively, sensitivity can be expressed (as it usually is) as the Rd at a specific dose of insulin, which may be low, intermediate, or a maximum dose. It is often assumed that steady-state rate of glucose uptake is reached by 180 min after onset of the insulin infusion. In fact, steady-state glucose uptake is not reached at 3h. Glucose uptake rate at 3h is only 2/3 the “true” steady-state, which is not achieved until 6h. Certainly, shorter periods (e.g. 120 min) are inadequate to reflect steady-state rates of uptake.

Read More »

MySugr

MySugr

This is an easy-to-use app that auto-logs daily blood sugars, insulin use, diet and activity data via connected devices. This app version allows patients to share Excel docs and PDFs of glucose history and other data to help providers make decisions about titrating insulin and advising on dietary modifications to tighten glycemic control.

Read More »

Medication Mystery

Test Your Knowledge

A 72-year-old patient arrives in your office complaining of shakiness and sweating before he went to bed the previous night. He doesn’t recall checking his blood glucose level at the time, however he felt better after a glass of milk and a few graham crackers. His current medications are metformin, pioglitazone, and glyburide. Which one of the following medications is the most likely cause of his symptoms? 1) Metformin 2) Pioglitazone 3) Glyburide Follow the link to see the right answer.

Read More »

International Textbook of Diabetes Mellitus, 4th Ed., Excerpt #84: Measuring Insulin Action In Vivo

DeFronzoCover

The glucose clamp: Rather than using exogenous agents that suppress beta-cell insulin secretion, the glucose clamp uses external feedback control to “open the loop” between insulin secretion and sensitivity. The glucose clamp is a powerful and widely used method to attain a quantitative measure of insulin sensitivity, and has been applied in many hundreds of experimental studies.

Read More »