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Production Assistant, Diabetes In Control

A1c Criteria

Which criteria other than fasting blood sugar do you feel is most important before providing an A1c test for your patients -- Weight, Family history, Hypertension, Age, Gender, Amount of physical activity? Follow the link to respond.

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International Textbook of Diabetes Mellitus, 4th Ed., Excerpt #134: Pathogenesis of Type 2 Diabetes Mellitus Part 5

First-phase insulin secretion: In response to i.v. glucose, insulin is secreted in a biphasic pattern with an early burst of insulin release within the first 10 min followed by a progressively increasing phase of insulin secretion that persists as long as the hyperglycemic stimulus is present. This biphasic insulin response is not observed after oral glucose, because of the more gradual rise in plasma glucose concentration. Loss of first-phase insulin secretion is a characteristic and early abnormality in patients destined to develop T2DM.

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