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Associations between Prediabetes and Vascular Complications

Oct 27, 2020
Editor: David L. Joffe, BSPharm, CDE, FACA

Author: Destiny Reed, PharmD. Candidate, Florida A&M College of Pharmacy and Pharmaceutical Sciences

Do patients with prediabetes share the same risk of vascular complications seen in patients with T2D? 

It is estimated that 33.9% of US adults have prediabetes. Though glucose metabolism is not impaired to the extent of type 2 diabetes, 30-50% of individuals with prediabetes develop T2D within five years of impaired metabolism onset. Lifestyle management is recommended to prevent the progression of prediabetes by reducing risk factors of T2D, such as promoting smoking cessation, dietary modification, and weight loss. Patients at higher risk of developing T2D (women with a history of GDM and individuals with a BMI ≥ 35 kg/m2 or >60 yrs old) can also be prescribed metformin for diabetes prevention. Prediabetes has been associated with higher cardiovascular risk, but associations between micro- and macrovascular complications commonly seen in patients with T2D are unclear.…


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