The STEP-Wise approach was developed from the results of a study.
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Throughout the study, the basal and bolus doses were titrated as needed according to patient self-monitored premeal and bedtime glucose levels. A1c was assessed after 12 weeks, and patients not at goal (less than 7%)added a second daily bolus injection, before their next largest meal. After another 12 weeks, patients still above goal added another injection, before their next largest meal.
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