SPECIAL FEATURE: Glucagon-like peptide 1 increases the period of postprandial satiety and slows gastric emptying in obese men

The regulation of food intake is a complex process involving psychologic, social, and physiologic components. Physiologically, it is generally assumed that food intake is regulated by a central feeding drive that is later counterregulated by peripheral satiety signals that are activated during a meal. These satiety signals have been suggested to include gut peptides and multiple signals via gastric and small-intestinal vagal afferent nerve fibers (1–4). Glucagon-like peptide 1(7-36) amide (GLP-1) is one peptide that has been implicated in the short-term regulation of food intake (5).