Sign up for our complimentary
weekly e-journal

Main Newsletter
Mastery Series
Therapy Series
 
Bookmark and Share | Print Article | Items for the Week Previous | All Articles This Week | Next
This article originally posted 22 February, 2013 and appeared in  CardiovascularWomen's HealthIssue 665

Beware of Calcium Supplements

Hazards of a high calcium intake….
Advertisement

Latest research examining the potential hazards of a high calcium intake finds an increased mortality risk among women with a high intake through diet and supplements. The authors emphasized that mortality was not increased with customary levels of calcium intake.

The study found an increased risk for death from both all causes and cardiovascular disease (CVD) above a certain threshold of calcium intake, although the authors say the risk increase was only moderate for women whose intake was exclusively through diet -- a more pronounced risk was seen among women with a high dietary intake who also used calcium supplements.

The study, included 61,433 women, born between 1914 and 1948, from a Swedish mammography cohort, established in 1987-1990. The researchers used data from food frequency and lifestyle questionnaires, completed by all the women at baseline and by 38,984 women in 1997, to establish their levels of calcium intake.

Using Swedish registry data, the researchers established that 11,944 (17%) women died during the median follow up of 19 years and 1,094,880 person-years at risk. Of these women, 3862 died of CVD, 1932 of ischemic heart disease, and 1100 of stroke.

Analysis showed that the highest rates of death from all causes and CVD, but not from stroke, were among women with the highest dietary calcium intake, above 1400 mg/day. Compared with dietary intakes of 600-1000 mg/day, calcium intake above this level was associated with 1.40, 1.49, and 2.14 times the risk for death from any cause, CVD, and ischemic heart disease, respectively.

These risk increases were seen after multivariable adjustment, and the authors note that a shift from lower to higher risk with the multivariable model was mainly the result of adjusting for use of calcium containing supplements.

A quarter of the study population in 1997 were taking calcium supplements; among these women, a high dietary calcium intake exceeding 1400 mg/day was associated with an even greater excess mortality risk.

In a separate analysis from the date of the second survey, stratified according to no use or type of calcium supplement use, women with the highest dietary calcium intake who took calcium tablets (500 mg per tablet) had a 2.57-fold increased risk for all cause mortality compared with those with a dietary intake of 600-999 mg/day, and those who took any type of calcium-containing supplement had a 1.51-fold increased risk, whereas the risk was not significant among non-users of calcium supplements.

The team wrote, "Thus among women with a high dietary intake of calcium, the addition of calcium supplements increased the risk of death in a dose dependent fashion."

Karl Michaëlsson (Uppsala University, Sweden) and team conclude that, "Our present data together with previous observations suggest that for the prevention of fractures in elderly people and simultaneous avoidance of possible serious adverse events related to a high calcium intake (such as higher risk of hip fracture, cardiovascular disease, renal stone, and, as observed in the current study, mortality) emphasis should be placed on people with a low intake of calcium rather than increasing the intake of those already consuming satisfactory amounts."

BMJ 2013; 346: f228 

Advertisement


 

Bookmark and Share | Print | Category | Home

This article originally posted 22 February, 2013 and appeared in  CardiovascularWomen's HealthIssue 665

Past five issues: Diabetes Clinical Mastery Series Issue 206 | SGLT-2 Inhibitors Special Edition September 2014 | Issue 746 | Diabetes Clinical Mastery Series Issue 205 | Humulin Insulin Special Edition September 2014 |

2014 Most Popular Articles:

Abbott Announces Approval of Its New Unique Continuous Glucose Monitor
Posted September 05, 2014
Diabetic Neuropathy Improved with Vegan Diet
Posted August 22, 2014
Low Carb Beats Low Fat
Posted September 05, 2014
CDC: 40% of American Adults Will Develop Diabetes
Posted August 22, 2014
Empagliflozin (Jardiance) SGLT-2 Inhibitor Now Available in Pharmacies
Posted August 29, 2014
Lilly's Basal Insulin Peglispro Demonstrated HbA1c Superiority against Lantus
Posted September 05, 2014
New Ultra-Rapid-Acting Insulin Formulation
Posted August 22, 2014
Pistachios Associated with an Improved Metabolic Risk Profile in Prediabetes
Posted August 29, 2014
FDA Approves J&J's Invokamet Combo (SGLT-2 + Metformin)
Posted August 15, 2014
Sensor Implant Measures Blood pH in Type 1 Diabetes
Posted August 29, 2014


Browse by Feature Writer & Article Category.
A. Lee Dellon, MD | Aaron I. Vinik, MD, PhD, FCP, MACP | Beverly Price | Charles W Martin, DD | Derek Lowe, PhD | Dr. Bernstein | Dr. Brian Jakes, Jr. | Dr. Fred Pescatore | Dr. Tom Burke, Ph.D | Eric S. Freedland | Evan D. Rosen | Ginger Kanzer-Lewis | Greg Milliger | Kristina Sandstedt | Laura Plunkett | Leonard Lipson, M.A. | Louis H. Philipson | Maria Emanuel Ryan, DDS, PhD | Marilyn Porter, RD, CDE | Melissa Diane Smith | Michael R. Cohen, RPh, MS, ScD, FASHP | Paul Chous, M.A., OD | Philip A. Wood PhD | R. Keith Campbell, Professor, B.Pharm, MBA, CDE | Sheri R. Colberg PhD | Sherri Shafer | Stanley Schwartz, MD, FACP, FACE | Steve Pohlit | Steven V. Edelman, M.D. | Timothy S. Hollingshead |

Cast Your Vote
Diabetes in Control is considering launching a store tab on the site with the ability to purchase A1C tests and other diagnostic test in bulk for medical professionals. What do you think?
CME/CE of the Week
Dina Green, MD

Category: General Diabetes
Credits: 1.0



Search Articles On Diabetes In Control